59721-29-8

• 常用中文名：甲磺酸卡莫司他
• 常用英文名：Camostat Mesylate
• CAS号：59721-29-8
• 分子式：C₂₁H₂₆N₄O₈S
• 分子量：494.518
• 相关类别： 生物化工 抑制剂 跨膜转运体(Transmembrane Transporters) Sodium Channel 抑制剂
• 发布时间：2018-09-18 13:05:46
• 更新时间：2026-07-23 07:51:31
• Camostat (FOY305; FOY-S980)甲磺酸盐是胰蛋白酶样蛋白酶抑制剂。

名称

• 中文名: 甲磺酸卡莫司他
• 英文名: Camostat Mesylate
• 中文别名: 4-(2-(2-(二甲基氨基)-2-氧代乙氧基)-2-氧代乙基)苯基4-胍基苯甲酸酯 甲磺酸盐; 甲磺酸卡莫斯塔; 甲磺酸卡莫司他,10 MM DMSO 溶液; 甲磺酸卡莫他特; 2-(二甲基氨基)-2-氧代乙基 4-(4-胍基苯甲酰氧基)苯基乙酸酯甲磺酸盐; CAMOSTAT MESYLATE,TMPRSS2抑制剂; FOY-S980)甲磺酸盐; 卡莫他特甲磺酸盐; 甲磺酸卡莫司他 CRS; FOY-S980|||甲磺酸卡莫司他|||FOY305|||CAMOSTAT MESILATE; Camostat mesylate 白色结晶粉末; 化合物：Camostat Mesilate; 化合物:Camostat Mesilate; 2-(二甲基氨基)-2-氧代乙基 4-(4-胍基苯甲酰氧基)苯乙酸酯甲磺酸盐; 卡莫司他甲磺酸盐
• 英文别名: 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-benzeneaceticaci2-(dimethylam; Camostat mesylate, 10 mM in DMSO; 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate; CAMOSTAT (FOY305; FOY-S980); Camostat Mesylate CRS; FOY-S; Camostate mesilate; Camostat Mesilate; n,n-dimethylcbamoylmethyl4-(4-guanidinobenzoyloxy)phenylacetatemethanesul; CAMOSTAT MESYLATE; Camostat MesylateQ: What is Camostat Mesylate Q: What is the CAS Number of Camostat Mesylate Q: What is the storage condition of Camostat Mesylate Q: What e the applications of Camostat Mesylate; CaMostat Mesilate, CaMostat Mesylate; Camostat Mesilate RS; Camostat Methanesulfonate; Camostat mesilate //BP; Foipan mesylate; Camostat mesilate; 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY-S980|||FOY305|||Camostat mesilate; Camostat Mesilate (FOY305); 4-Guanidinobenzoic acid 4-[[[(dimethylcbamoyl)methoxy]carbonyl]methyl]phenyl·methanesulfonic acid; Benzeneacetic acid, 4-[[4-[(aMinoiMinoMethyl)amino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester, Methanesulfonate; [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate,methanesulfonic acid; 4-(2-(2-(diMethylaMino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate Methanesulfonate; Camostat mesylate - Bio-X; Camostat Mesylate >; 4-{2-[(diMethylcbaMoyl)Methoxy]-1-(Methanesulfonyloxy)-2-oxoethyl}phenyl 4-cbaMiMidaMidobenzoate; 4-{2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate methanesulfonate (1:1); Camostat (FOY305; MFCD00941410; 4-[[4-[(AMINOIMINOMETHYL)AMINO]BENZOYL]OXY]BENZENEACETIC ACID 2-(DIMETHYLAMINO)-2-OXOETHYL ESTER METHANESULFONATE; FOY305; Camorestat mesylate; Camostat mesylate (Camostat mesilate); Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1); Camostat mesylate(FOY-305); Camosetam mesylate; p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcbamoylmethyleste; Camostat mesylate, TMPRSS2 inhibitor; ino)-2-oxoethylester,monomethanesulfonate; Camostatemesylate; Foipan; Camostat (mesylate)

物化性质

• 沸点: 634.6ºC at 760 mmHg
• 熔点: 150-1550C
• 分子式: C₂₁H₂₆N₄O₈S
• 分子量: 494.518
• 精确质量: 494.147125
• PSA: 197.56000
• LogP: 2.84290
• 外观性状: 结晶固体
• 储存条件:

  在密封的贮藏器内，并放置阴凉，干燥的地方保存

• 稳定性:

  避免接触水

• 水溶解性: 水溶性：微溶；极微溶：乙醇；不溶：乙醚
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:3

  3.氢键受体数量:9

  4.可旋转化学键数量:9

  5.互变异构体数量:4

  6.拓扑分子极性表面积200

  7.重原子数量:34

  8.表面电荷:0

  9.复杂度:695

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：未确定

  2. 密度（g/cm³ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：150-155

  5. 沸点（ºC）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（°）：未确定

  8. 闪点（℉）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/mL，)：水：未确定

生物活性

• 描述: Camostat (FOY305; FOY-S980)甲磺酸盐是胰蛋白酶样蛋白酶抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Okuno, M., et al., Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001. 120(7): p. 1784-800.

  [2]. Yamamoto, A., et al., Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res, 1994. 11(10): p. 1496-500.

  [3]. Gibo, J., et al., Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. Lab Invest, 2005. 85(1): p. 75-89.

毒性和生态

毒理学数据: 1、急性毒性：大鼠经口LD50： 3 gm /kg；大鼠皮下注射LD50：1320 mg/kg；大鼠静脉注射LD50：152 mg/kg； 小鼠经口 LD50 ： 3 gm /kg ；小鼠皮下注射 LD50 ：1400 mg/kg ；小鼠静脉注射 ：200 mg/kg ； 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 生态学数据: 对水是稍微危害的，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : CY1571620 CHEMICAL NAME : Benzeneacetic acid, 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-, 2-(dimethylamino)-2- oxoethyl ester, monomethanesulfonate CAS REGISTRY NUMBER : 59721-29-8 LAST UPDATED : 198708 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C20-H22-N4-O5.C-H4-O3-S MOLECULAR WEIGHT : 494.57 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 27,719,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 152 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 27,719,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985

安全

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H315-H319-H335-H400
• 警示性声明: P261-P273-P305 + P351 + P338
• 危害码 (欧洲): Xi,N
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: UN 3077 9 / PGIII
• RTECS号: UV7720000

合成路线

59721-16-3 ~% 59721-29-8

文献：US4021472 A1, ;

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