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59721-29-8

59721-29-8 structure
59721-29-8 structure
  • Name: Camostat Mesylate
  • Chemical Name: Camostat Mesylate
  • CAS Number: 59721-29-8
  • Molecular Formula: C21H26N4O8S
  • Molecular Weight: 494.518
  • Catalog: Biochemical Inhibitor Transmembrane Transporters Sodium Channel inhibitor
  • Create Date: 2018-09-18 13:05:46
  • Modify Date: 2026-07-23 07:51:31
  • Camostat Mesylate(FOY305; FOY-S980) is a trypsin-like protease inhibitorTarget: Trypsin-like proteaseCamostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs [1]. Camostat mesilate (20 mM) combined with insulin results a significant hypoglycemic effect following large intestinal administration. Camostat mesilate (20 mM) is effective in reducing insulin degradation in both small and large intestinal homogenates of rats [2]. Camostat mesilate (2 mM) inhibits MCP-1 and TNF- production in activated rat monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production of cultured rat PSCs. Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function of rat chronic pancreatitis induced by DBTC. Camostat mesilate (1 mg/g) inhibits chronic inflammation and pancreatic fibrosis induced by DBTC. Camostat mesilate (1 mg/g) inhibits the development of pancreatic fibrosis and PSCs activation in the pancreas induced by DBTC. Camostat mesilate (1 mg/g) suppresses monocytes infiltration and inhibits MCP-1 expression both in serum and in pancreatic tissue [3].
Name Camostat Mesylate
Synonyms 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-benzeneaceticaci2-(dimethylam
Camostat mesylate, 10 mM in DMSO
2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate
CAMOSTAT (FOY305; FOY-S980)
Camostat Mesylate CRS
FOY-S
Camostate mesilate
Camostat Mesilate
n,n-dimethylcbamoylmethyl4-(4-guanidinobenzoyloxy)phenylacetatemethanesul
CAMOSTAT MESYLATE
Camostat MesylateQ: What is Camostat Mesylate Q: What is the CAS Number of Camostat Mesylate Q: What is the storage condition of Camostat Mesylate Q: What e the applications of Camostat Mesylate
CaMostat Mesilate, CaMostat Mesylate
Camostat Mesilate RS
Camostat Methanesulfonate
Camostat mesilate //BP
Foipan mesylate
Camostat mesilate
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate
FOY-S980|||FOY305|||Camostat mesilate
Camostat Mesilate (FOY305)
4-Guanidinobenzoic acid 4-[[[(dimethylcbamoyl)methoxy]carbonyl]methyl]phenyl·methanesulfonic acid
Benzeneacetic acid, 4-[[4-[(aMinoiMinoMethyl)amino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester, Methanesulfonate
[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate,methanesulfonic acid
4-(2-(2-(diMethylaMino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate Methanesulfonate
Camostat mesylate - Bio-X
Camostat Mesylate >
4-{2-[(diMethylcbaMoyl)Methoxy]-1-(Methanesulfonyloxy)-2-oxoethyl}phenyl 4-cbaMiMidaMidobenzoate
4-{2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate methanesulfonate (1:1)
Camostat (FOY305
MFCD00941410
4-[[4-[(AMINOIMINOMETHYL)AMINO]BENZOYL]OXY]BENZENEACETIC ACID 2-(DIMETHYLAMINO)-2-OXOETHYL ESTER METHANESULFONATE; FOY305
Camorestat mesylate
Camostat mesylate (Camostat mesilate)
Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester, methanesulfonate (1:1)
Camostat mesylate(FOY-305)
Camosetam mesylate
p-(p-guanidinobenzoyloxy)phenylaceticacid,n,n-dimethylcbamoylmethyleste
Camostat mesylate, TMPRSS2 inhibitor
ino)-2-oxoethylester,monomethanesulfonate
Camostatemesylate
Foipan
Camostat (mesylate)
Description Camostat Mesylate(FOY305; FOY-S980) is a trypsin-like protease inhibitorTarget: Trypsin-like proteaseCamostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs [1]. Camostat mesilate (20 mM) combined with insulin results a significant hypoglycemic effect following large intestinal administration. Camostat mesilate (20 mM) is effective in reducing insulin degradation in both small and large intestinal homogenates of rats [2]. Camostat mesilate (2 mM) inhibits MCP-1 and TNF- production in activated rat monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production of cultured rat PSCs. Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function of rat chronic pancreatitis induced by DBTC. Camostat mesilate (1 mg/g) inhibits chronic inflammation and pancreatic fibrosis induced by DBTC. Camostat mesilate (1 mg/g) inhibits the development of pancreatic fibrosis and PSCs activation in the pancreas induced by DBTC. Camostat mesilate (1 mg/g) suppresses monocytes infiltration and inhibits MCP-1 expression both in serum and in pancreatic tissue [3].
Related Catalog
References

[1]. Okuno, M., et al., Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001. 120(7): p. 1784-800.

[2]. Yamamoto, A., et al., Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res, 1994. 11(10): p. 1496-500.

[3]. Gibo, J., et al., Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. Lab Invest, 2005. 85(1): p. 75-89.
Boiling Point 634.6ºC at 760 mmHg
Melting Point 150-1550C
Molecular Formula C21H26N4O8S
Molecular Weight 494.518
Exact Mass 494.147125
PSA 197.56000
LogP 2.84290
Storage condition Desiccate at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1571620
CHEMICAL NAME :
Benzeneacetic acid, 4-((4-((aminoiminomethyl)amino)benzoyl)oxy)-, 2-(dimethylamino)-2- oxoethyl ester, monomethanesulfonate
CAS REGISTRY NUMBER :
59721-29-8
LAST UPDATED :
198708
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H22-N4-O5.C-H4-O3-S
MOLECULAR WEIGHT :
494.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 27,719,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 27,719,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H315-H319-H335-H400
Precautionary Statements P261-P273-P305 + P351 + P338
Hazard Codes Xi,N
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
RIDADR UN 3077 9 / PGIII
RTECS UV7720000
59721-16-3 structure

59721-16-3

~%

59721-29-8 structure

59721-29-8

Literature: US4021472 A1, ;
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