75225-51-3

• 常用中文名：洛伐他汀钠
• 常用英文名：LOVASTATIN HYDROXY ACID, SODIUM SALT
• CAS号：75225-51-3
• 分子式：C₂₄H₃₈O₆
• 分子量：422.55
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-05-30 08:00:00
• 更新时间：2024-01-09 15:16:15
• 洛伐他汀酸(甲长春花酸)是洛伐他汀的活性代谢产物,是一种有效的竞争性HMG-CoA还原酶抑制剂,Ki为0.6 nM[1]。

名称

• 中文名: 洛伐他汀钠
• 英文名: mevinolinic acid
• 中文别名: 洛伐他汀羟基酸钠盐
• 英文别名: 2-methoxy-4,4'-dihydroxychalcone; Echinantin; 4',4-dihydroxy-2-methoxychalcone; LOVASTATIN HYDROXY ACID, SODIUM SALT; Echinatin; Mevinolinic acid; lovastatin acid; loureirin C; lovastatin hydroxy acid

物化性质

• 密度: 1.14g/cm3
• 沸点: 602.3ºC at 760 mmHg
• 分子式: C₂₄H₃₈O₆
• 分子量: 422.55
• 闪点: 199.1ºC
• 精确质量: 447.26800
• PSA: 106.89000
• LogP: 2.38090
• 折射率: 1.537

生物活性

• 描述: 洛伐他汀酸(甲长春花酸)是洛伐他汀的活性代谢产物,是一种有效的竞争性HMG-CoA还原酶抑制剂,Ki为0.6 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
• 靶点:

  Ki: 0.6 nM (HMG-CoA reductase)[1]

• 参考文献:

  [1]. Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QJ7180000 CHEMICAL NAME : 1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))- CAS REGISTRY NUMBER : 75225-51-3 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C24-H38-O6.H3-N MOLECULAR WEIGHT : 439.66 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 749 mg/kg SEX/DURATION : female 6-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983

合成路线

75330-75-5 ~% 75225-51-3 151006-15-4 132748-10-8

文献：DIVERSA CORPORATION Patent: WO2005/40107 A2, 2005 ; Location in patent: Page/Page column 77-80 ;

75330-75-5 ~% 75225-51-3

文献：Nagasawa, Kazuki; Muraki, Yuichi; Matsuda, Tomoko; Ohnishi, Noriaki; Yokoyama, Teruyoshi Journal of Pharmaceutical Sciences, 2000 , vol. 89, # 12 p. 1594 - 1604

132748-10-8 ~% 75225-51-3

文献：Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

87069-91-8 132748-10-8 ~% 75225-51-3

文献：Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

945630-22-8 132748-10-8 ~% 75225-51-3

文献：Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

1730-91-2 132748-10-8 ~% 75225-51-3

文献：Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

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