75225-51-3

75225-51-3 structure

Name: LOVASTATIN HYDROXY ACID, SODIUM SALT
Chemical Name: mevinolinic acid
CAS Number: 75225-51-3
Molecular Formula: C₂₄H₃₈O₆
Molecular Weight: 422.55
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2018-05-30 08:00:00
Modify Date: 2025-08-25 20:56:26
Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1].

Name	mevinolinic acid
Synonyms	2-methoxy-4,4'-dihydroxychalcone Echinantin 4',4-dihydroxy-2-methoxychalcone LOVASTATIN HYDROXY ACID, SODIUM SALT Echinatin Mevinolinic acid lovastatin acid loureirin C lovastatin hydroxy acid

Description	Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Target	Ki: 0.6 nM (HMG-CoA reductase)[1]
References	[1]. Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

CHEMICAL NAME :: 1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))-

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983

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Literature: DIVERSA CORPORATION Patent: WO2005/40107 A2, 2005 ; Location in patent: Page/Page column 77-80 ;

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