上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：苯甲基磺酰氟
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

南通润丰石油化工有限公司
江苏省南通市崇川区
产品名：苄磺酰氟
纯度：99.5%
规格：1kg/1ton
联系人：曹经理
联系电话：17625439817

上海吉至生化科技有限公司
上海市上海市奉贤区
产品名：苯甲基磺酰氟
纯度：98.0%
规格：25g/5g
联系人：刘佳
联系电话：18116092098

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：苯甲基磺酰氟(PMSF)
纯度：98.0%
规格：100g/25g/5g/1ml
联系人：阿拉丁
联系电话：400-620-6333

中山市迪欣化工有限公司
广东省中山市三角镇
产品名：苯甲基磺酰氟（PMSF）
纯度：99.0%
规格：1kg
联系人：陈雪萍
联系电话：19129093253

武汉吉鑫益邦生物科技有限公司
湖北省武汉市江汉区
产品名：苄磺酰氟
纯度：99.0%
规格：500g/1kg/25kg/200kg
联系人：周美玲
联系电话：13260558730

湖北魏氏化学试剂股份有限公司
湖北省武汉市洪山区
产品名：苯甲基磺酰氟
纯度：98.0%
规格：5mg/25mg/10g/50g
联系人：张栋
联系电话：18717199209

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329-98-6生产厂家

329-98-6价格

329-98-6

329-98-6结构式

常用中文名：苄磺酰氟
常用英文名：PMSF
CAS号：329-98-6
分子式：C₇H₇FO₂S
分子量：174.193
相关类别：化学试剂有机试剂磺酸盐/亚磺酸盐
发布时间：2018-07-06 10:45:11
更新时间：2024-01-02 18:16:42
PMSF是通常用于制备细胞裂解物的不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。

化源商城直购

中文名	苯甲基磺酰氟
英文名	phenylmethanesulfonyl fluoride
中文别名	苯甲磺酰氟苄磺酰氟苄基磺酰氟 PMSF 苯甲基磺酰氟
英文别名	α-Toluenesulfonyl fluoride Benzenemethanesulfonyl fluoride Phenylmethanesulfonyl fluoride (PMSF) Phenylmethylsulfonyl fluoride Phenylmethanesulfonyl fluoride Phenylmethanesulphonyl fluoride Fluoride, Phenylmethanesulfonyl phenyl methane sulfonyl fluoride phenylmethyl-sulfonyl fluoride PMSF EINECS 206-350-2 Benzylsulfonyl Fluoride Benzylsulphonyl fluoride MFCD00007421

描述	PMSF是通常用于制备细胞裂解物的不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 组织蛋白酶研究领域 >> 其他
体外研究	PMSF(2mM)在Li +存在下抑制卡巴胆碱刺激的肌醇磷酸累积仅15％-19％。 PMSF对磷酸肌醇转换的抑制是由于磷酸肌醇分解后的一个或多个步骤[1]。 PMSF抑制T.brucei的血流中GPI中间体的肌醇残基的酰化。 PMSF抑制糖脂C的形成但不抑制体外脂肪酸重塑。 PMSF抑制了在procyclic锥虫中添加GPI酰化和乙醇胺磷酸酶,但在Hela细胞中没有[2]。
体内研究	PMSF(0.1mL/10g b.wt,ip)产生抗伤害感受,如甩尾潜伏期评估中％MPE的剂量响应性增加所示,但未能产生明确的剂量反应性运动抑制。接受腹膜内注射PMSF的小鼠表现出大麻素效应,包括抗伤害感受,体温过低和不动,ED50值分别为86,224和206mg/kg。 PMSF(30 mg/kg)预处理增强了anandamide对甩尾反应(抗伤害感受),自发活动和活动性的影响,分别为5倍,10倍和8倍[3]。
动物实验	在测定中使用重18至25g的雄性ICR小鼠。将PMSF溶解在芝麻油中，并以0.1mL / 10g b.wt的体积腹膜内施用。在静脉注射anandamide或载体注射前10分钟始终给予PMSF。使小鼠适应评估室过夜而不中断食物或水。在静脉注射anandamide或载体给药后，如下评价每只动物：5分钟的甩尾潜伏期（抗伤害感受）反应和5至15分钟的自发（运动）活动;或核心（直肠）温度5分钟和环固定（僵住症）5至10分钟。
参考文献	[1]. Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5(3): p. [2]. Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269(28): p. 18694-701. [3]. Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283(3): p. 1138-43.

密度	1.3±0.1 g/cm3
沸点	285.7±19.0 °C at 760 mmHg
熔点	92-95 °C
分子式	C₇H₇FO₂S
分子量	174.193
闪点	126.6±21.5 °C
精确质量	174.015076
PSA	42.52000
LogP	2.33
外观性状	白色至奶油色固体
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.522
储存条件	室温保存。
水溶解性	hydrolysis
分子结构	1、摩尔折射率：40.31 2、摩尔体积（m³/mol）：132.2 3、等张比容（90.2K）：336.7 4、表面张力（dyne/cm）：42.0 5、极化率（10 ^-24cm ³）：15.98
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:3 4.可旋转化学键数量:2 5.互变异构体数量:无 6.拓扑分子极性表面积42.5 7.重原子数量:11 8.表面电荷:0 9.复杂度:199 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	一、物性数据性状：白色至微黄色粉末密度（g/mL,25/4℃）：0.797 相对蒸汽密度（g/mL,空气=1）：不可用熔点（ºC）：90-94 沸点（ºC,常压）：112 沸点（ºC,5.2kPa）：不可用折射率：不可用闪点（ºC）：不可用比旋光度（º）：不可用自燃点或引燃温度（ºC）：不可用蒸气压（kPa,25ºC）：不可用饱和蒸气压（kPa,60ºC）：不可用燃烧热（KJ/mol）：不可用临界温度（ºC）：不可用临界压力（KPa）：不可用油水（辛醇/水）分配系数的对数值：不可用爆炸上限（%,V/V）：不可用爆炸下限（%,V/V）：不可用溶解性：难溶于水，且在水溶液中非常不稳定，容易分解。可溶于异丙醇、乙醇、甲醇、二甲苯和石油醚。

Name:	alpha-Toluenesulfonyl fluoride 99% Material Safety Data Sheet
Synonym:	Phenylmethylsulfonyl fluoride; PMSF; Benzenemethanesulfonyl fluorid
CAS:	329-98-6

Section 1 - Chemical Product MSDS Name:alpha-Toluenesulfonyl fluoride 99% Material Safety Data Sheet
Synonym:Phenylmethylsulfonyl fluoride; PMSF; Benzenemethanesulfonyl fluorid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
329-98-6	alpha-Toluenesulfonyl fluoride	99.0	206-350-2

Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Causes burns.Moisture sensitive.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
Causes skin burns.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Antidote: None reported.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Do NOT use water directly on fire. Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use with adequate ventilation. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Keep containers tightly closed.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 329-98-6: United States OSHA: 2.5 mg/m3 TWA (as F) (listed under Fluorides Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Needles
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 92.00 - 94.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: hydrolysis
Specific Gravity/Density:
Molecular Formula: C7H7FO2S
Molecular Weight: 174.19

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, moisture.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 329-98-6: XT8040000 LD50/LC50:
CAS# 329-98-6: Oral, mouse: LD50 = 200 mg/kg.
Carcinogenicity:
alpha-Toluenesulfonyl fluoride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, N.O.S.*
Hazard Class: 8
UN Number: 1759
Packing Group: II
IMO
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing Group: II
RID/ADR
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing group: II

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 329-98-6: No information available.
Canada
CAS# 329-98-6 is listed on Canada's DSL List.
CAS# 329-98-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 329-98-6 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

二、毒理学数据：

急性毒性：不可用。

生态学数据:

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT8040000

CHEMICAL NAME :: alpha-Toluenesulfonyl fluoride

CAS REGISTRY NUMBER :: 329-98-6

BEILSTEIN REFERENCE NO. :: 2088311

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H7-F-O2-S

MOLECULAR WEIGHT :: 174.20

WISWESSER LINE NOTATION :: WSF1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 173,33,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,265,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 31,1193,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4865 No. of Facilities: 104 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2391 (estimated) No. of Female Employees: 1942 (estimated)

符号	GHS05, GHS06
信号词	Danger
危害声明	H301-H314
警示性声明	P280-P305 + P351 + P338-P310
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T:Toxic;
风险声明 (欧洲)	R25;R34
安全声明 (欧洲)	S7-S16-S45-S36/37/39-S28A-S26
危险品运输编码	UN 3261 8/PG 2
WGK德国	3
RTECS号	XT8050000
包装等级	III
危险类别	8
海关编码	2904909090

150-60-7

~88%

329-98-6

文献：Kirihara, Masayuki; Naito, Sayuri; Nishimura, Yuki; Ishizuka, Yuki; Iwai, Toshiaki; Takeuchi, Haruka; Ogata, Tomomi; Hanai, Honoka; Kinoshita, Yukari; Kishida, Mari; Yamazaki, Kento; Noguchi, Takuya; Yamashoji, Shiro Tetrahedron, 2014 , vol. 70, # 14 p. 2464 - 2471

150-60-7

~9%

329-98-6

16601-40-4

文献：Tetrahedron Letters, , vol. 52, # 24 p. 3086 - 3089

16601-40-4

~88%

329-98-6

上游产品 2
150-60-7 16601-40-4
下游产品 10
$1-morpholin-4-yl-8-phenyl-7$l^{6}-thiabicyclo[4.2.0]octane 7,7-dioxide结构式$ 19158-30-6 1885-38-7 614-47-1 1896-62-4
23566-06-5 645-49-8 10271-81-5 100-87-8
1608-31-7 4192-77-2

海关编码	2904909090
中文概述	2904909090 其他烃的磺化、硝化、亚硝化衍生物（不论是否卤化）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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