113617-63-3

• 常用中文名：奥比沙星
• 常用英文名：Orbifloxacin
• CAS号：113617-63-3
• 分子式：C₁₉H₂₀F₃N₃O₃
• 分子量：395.376
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-07-06 14:31:10
• 更新时间：2026-07-04 13:55:42
• Orbifloxacin是一种合成的氟喹诺酮类广谱抗生素,已被批准用于犬类。

名称

• 中文名: 奥比沙星
• 英文名: Orbifloxacin
• 中文别名: 1-环丙基-5,6,8-三氟-1,4-二羟基-7-(顺式-3,5-二甲基-1-哌嗪基)-4-氧代-喹啉-3-羧酸; 奥比沙星标准品; 奥比沙星溶液, 100UG/ML 甲醇溶液; 奥比沙星溶液, 1000UG/ML 甲醇溶液; 甲醇中奥比沙星; 奥比沙星杂质混合 标准品; 奥比沙星/A1A; 奥比沙星,10 MM DMSO 溶液; 甲醇( N,N二甲基甲酰胺)中奥比沙星; 甲醇/二甲基亚砜中奥比沙星溶液, 1000ΜG/ML; 奥比沙星溶液, 1000PPM; 奥比沙星 113-3; 奥比沙星 标准品; 1-环丙基-5,6,8-三氟-7-(CIS-3,5-二甲基哌嗪)-1,4-二氢-4-氧-喹啉-3-羧酸; 1-环丙基-5,6,8-三氟-7-(Cis-3,5-二甲基哌嗪)-1,4-二氢-4-氧-喹啉-3-羧酸; 奥比沙星Orbifloxacin; 1-环丙基-5,6,8-三氟-7-(顺式-3,5-二甲基哌嗪)-1,4-二氢-4-氧代喹啉-3-羧酸; 奥比沙星-D4; 奥比沙星溶液,100PPM; 三氯苯咪唑; 奥比沙星杂质混合物/A1A; 奥比沙星检测标准品
• 英文别名: 1-cyclopropyl-7-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; orbifloxacin:1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-QUINOLINE-3-cboxylic acid; Orbifloxacin, 10 mM in DMSO; 1-Cyclopropyl-5,6,8-trifluoro-7-(3α,5α-dimethyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecboxylic acid; ORBAX; Orbifloxacin Solution, 100ppm; Orbax, 1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-cboxylic acid; Orbifloxacin impurity mixture CRS; Orbifloxacin CRS; 1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-cboxylic Acid; ORBIFLOXACIN; Mufloxacin; 1-CYCLOPROPYL-6,7,8-TRIFLUORO-4-OXO-3-QUINOLINE CBOXYLIC ACID; Orbifloxacin //BP; 1-Cyclopropyl-5.6.8-trifluoro-7-(cis-3,5-dimethylpiperazine)-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; Orbifloxacin Standd; Mr Than the effect of; 3-Quinolinecboxylic acid, 1-cyclopropyl-7-(3R,5S)-3,5-dimethyl-1-piperazinyl-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel; 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; Orbifloxacin, Vetranal; 104354; 1-CYCLOPROPYL-5,6,8-TRIFLUORO-1,4-DIHYDRO-7-(CIS-3,5-DIMETHYL-1-PIPERAZINYL)-4-OXO-QUINOLINE-3-CBOXYLIC ACID; 1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(3β,5β-dimethyl-1-piperazinyl)-4-oxoquinoline-3-cboxylic acid; 1-CYCLOPROPYL-7-(3,5-DIMETHYL-PIPERAZIN-1-YL)-5,6,8-TRIFLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CBOXYLIC ACID; Orbifloxacin solution Methanol/DMSO, 1000μg/mL; Orbifloxacin in Methanol( DMF); Orbifloxacin solution,1000ppm; 1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-5,6,8-trifluoro-4-oxo-quinoline-3-cboxylic acid; Orbifloxacin,1-Cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxo-quinoline-3-cboxylic acid, Orbax; 1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-5,6,8-trifluoro-4-oxo-3-quinolinecboxylic acid; 1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-5,6,8-trifluoro-4-oxoquinoline-3-carboxylic acid; Orbax; 1-Cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; Obixacin; MFCD00864858

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 590.7±50.0 °C at 760 mmHg
• 熔点: 260 °C(dec.)
• 分子式: C₁₉H₂₀F₃N₃O₃
• 分子量: 395.376
• 闪点: 311.1±30.1 °C
• 精确质量: 395.145691
• PSA: 74.57000
• LogP: 2.37
• 外观性状: 固体;White to Orange to Green powder to crystal
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.588
• 储存条件: 室温

生物活性

• 描述: Orbifloxacin是一种合成的氟喹诺酮类广谱抗生素,已被批准用于犬类。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

合成路线

106890-70-4 21655-48-1 ~72% 113617-63-3

文献：Miyamoto, Teruyuki; Matsumoto, Jun-ichi; Chiba, Katsumi; Egawa, Hiroshi; Shibamori, Koh-ichiro; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1645 - 1656

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