11015-37-5

• 常用中文名：黄霉素
• 常用英文名：Bambermycin
• CAS号：11015-37-5
• 分子式：C₆₉H₁₀₇N₄O₃₅P
• 分子量：1582.583
• 相关类别： 原料药 饲料药物添加剂
• 发布时间：2018-06-15 19:32:56
• 更新时间：2026-07-02 09:16:49
• Moenomycin complex 是有效的 transglycosylase 抑制剂。Moenomycin complex 通过阻断 A 类青霉素结合蛋白 (PBPs) 转糖基酶活性抑制细菌生长。
• 1、药效学 黄霉素为磷酸化多糖类抗生素，其抗菌作用机理是通过干扰细胞壁的结构物质肽聚糖的生物合成从而抑制细菌的繁殖。黄霉素的促生长原理可能在于它能提高饲料中能量和蛋白质的消化；能使肠壁变薄从而提高营养物质的吸收；能有效地维持肠道菌群的平衡和瘤胃pH值的稳定。细菌对黄霉素不易产生耐药性，黄霉素也不易与其他抗生素产生交叉耐药性，黄霉素抗菌谱较窄，主要对革兰氏阳性菌有效，且对其他抗生素耐药的革兰氏阳性菌也有效，但对革兰氏阴性菌作用很弱。2、药动学 黄霉素经口投药后几乎不被消化道吸收，24h后几乎全部由粪便排出。肉鸡以推荐剂量的350倍、产蛋鸡以推荐剂量的25倍、猪和肉牛以推荐剂量的16倍混饲，屠宰后在血、肌肉、肝脏、肾脏、皮肤、脂肪和蛋中均未检出黄霉素残留，牛每日以45mg剂量连续投服370天后，在牛奶中未检出残留。3、毒理学黄霉素毒性极低，雄性小鼠的LD50：内服大于10g/kg，腹腔注射为1520mg/kg。4、药物相互作用 黄霉素与其他抗生素不产生拮抗作用，可与磺胺药、泰妙菌素、红霉素、林可霉素和离子载体抗球虫药配伍使用。 
   

名称

• 中文名: 黄霉素
• 英文名: bambermycin
• 中文别名: 班贝霉素/黄霉素; 莫诺霉素复合物; 富乐雪; 黄霉素(定性); 默诺霉素A; 黄霉素 标准品; 默诺霉素/班贝霉素/黄磷脂醇/黄磷脂素/默诺霉素A/班伯霉素; 黄霉素 MOENOMYCIN COMPLEX; 默诺霉素; 黄磷脂醇素(FLAVOPHOSPHOLIPOL,FV); 黄霉素11-5; 黄磷脂素; 班贝霉素; 诺霉素; 默诺霉素复合物; 班伯霉素(BAMBERMYCINS,BM); 黄磷脂醇; 黄霉素预混剂; 富拉磷
• 英文别名: bambermycin (API); (2R)-3-{[{[(2R,3R,4R,5S,6S)-3-{[(2S,3R,4R,5S,6R)-3-Acetamido-5-{[(2S,3R,4R,5S,6R)-3-acetamido-4-hydroxy-6-methyl-5-({(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)carbamoyl]tetrahydro-2H-pyran-2-yl}oxy)tetrahydro-2H-pyran-2-yl]oxy}-4-hydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-6-carbamoyl-4-(carbamoyloxy)-5-hydroxy-5-methyltetrah; Moenomycin Complex (Mixture of Moenomycin A, Moenomycin A12, Moenomycin C1, Moenomycin C3, Moenomycin C4); Flavomycin //BP; Bambermycine; BAMBERMYCIN(FLAVOMYCIN); Bambermycins, Moenomycin; Flavomycin Premix; Moenomycin Complex (~ Over CaCO3); Moenomycin complex (>; Flavomycine; (2S,3S,4R,5R,6R)-5-(((2S,3R,4R,5S,6R)-3-acetaMido-5-(((2S,3R,4R,5S)-3-acetaMido-4-hydroxy-6-Methyl-5-(((2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-((2-hydroxy-5-oxocyclopent-1-en-1-yl)cbaMoyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy; FLAVOMYCIN; MOENOMYCIN; (2S,3S,4R,5R,6R)-5-(((2S,3R,4R,5S,6R)-3-Acetamido-5-(((2S,3R,4R,5S)-3-acetamido-4-hydroxy-6-me; Flavomyci; FlavomycinQ: What is Flavomycin Q: What is the CAS Number of Flavomycin Q: What is the storage condition of Flavomycin; MoenoMycin coMplex; Moenomycine; Flavophespholipol; menomycin; BAMBERMYCINS; Flavomycin - premix; Flavomycin; moenomycin a; YUHUNJI; Flavomycin (, Mixture of congeners); BAMBERMYCIN; flavophospholipol

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₆₉H₁₀₇N₄O₃₅P
• 分子量: 1582.583
• 精确质量: 1581.661377
• PSA: 611.69000
• LogP: 4.81
• 折射率: 1.615
• 储存条件: 0-6°C

生物活性

• 描述: Moenomycin complex 是有效的 transglycosylase 抑制剂。Moenomycin complex 通过阻断 A 类青霉素结合蛋白 (PBPs) 转糖基酶活性抑制细菌生长。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Transglycosylase[1]

• 参考文献:

  [1]. Cheng TJ, et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):431-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QA3020000 CHEMICAL NAME : Moenomycin CAS REGISTRY NUMBER : 11015-37-5 LAST UPDATED : 198910 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,740,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,740,1978 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - wakefulness Behavioral - somnolence (general depressed activity) REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,743,1965

安全

• 危害声明: H413
• 风险声明 (欧洲): 53
• 危险品运输编码: UN 3077 9 / PGIII
• RTECS号: QA3020000

制备

【方法1】
由灰绿链霉菌发酵而得。以葡萄糖、大豆粕和食盐为培养基，经深层发酵培养，发酵液经喷雾干燥得到产品。