110351-94-5

• 常用中文名：(S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃O[3,4-F]吲哚嗪-3,6,10(4H)-酮
• 常用英文名：(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
• CAS号：110351-94-5
• 分子式：C₁₃H₁₃NO₅
• 分子量：263.25
• 相关类别： 信号通路 抗体- 药物偶联物 ADC细胞毒素
• 发布时间：2018-12-18 16:57:01
• 更新时间：2026-06-30 21:08:18
• Exatecan中间体1(化合物6)是Exatecan(DX-8951、HY-13631)的中间体。Exatecan是一种抗癌剂,属于喜树碱类似物类。Exatecan通过与DNA相互作用干扰肿瘤细胞的增殖和分裂,从而抑制肿瘤生长。Exatecan主要用于研究多种癌症,包括卵巢癌、肺癌和乳腺癌[1][2]。

名称

• 中文名: 7-乙基-10-羟基喜树碱中间体
• 英文名: (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
• 中文别名: 三并环中间体; (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃O[3,4-F]吲哚嗪-3,6,10-酮; (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]吲哚嗪-3,6,10(4H)-三酮; 依喜替康 EXB; 伊立替康杂质64; (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]中氮茚-3,6,10(4H)-三酮; (4S)-4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-F]吲嗪-3,6,10(4H)-三酮; 依喜替康中间体片段A; (4S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃O[3,4-F]吲哚嗪-3,6,10(4H)-酮; ((4S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]吲哚嗪-3,6,10(4H)-三酮; 10KG每月,也是伊立替康中间体; 依喜替康中间体EXATECAN; (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]吲嗪-3,6,10(4H)-三酮; 依喜替康杂质3; (S)-4-乙基-4-羟基7,8-氢-1H-吡喃O[3,4F]吲哚嗪-3,6, 10(4H)-酮; 7-乙基-10-羟基喜树碱中间体/110-5; NA(依喜替康中间体); 喜树碱CDE环中间体; (4S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]吲嗪-3,6,10(4H)-三酮; 三并环(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE; (S)-4-乙基-4-羟基-7,8-二氢-1H-吡喃并[3,4-F]中氮茚-3,6,10(4H)-三酮(伊喜替康F片段9106F)
• 英文别名: (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)trione; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione; Exatecan Impurity 3; 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S); 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (S); Exatecan intermediates; 8-DIHYDRO-1H-PYRANO[3; (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolidin-3,6,10(4H)-trione; Irinotecan Impurity 64; Exatecan Intermediate 1; Trihydroxy lactone; (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione; (4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione; (S)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro- 6-oxa-3-aza-cyclopenta [beta] naphthalene-1,4,7-trione; 4-F]INDOLIZINE-3; (S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE 110-5; (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE; (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; (S) 4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano O [3,4-F] indoleazine-3,6,10 - one; 10(4H)-TRIONE; (S)-trione; RUBI-006; (S)-4-ETHYL-4-HYDROXY-7; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 666.6±55.0 °C at 760 mmHg
• 分子式: C₁₃H₁₃NO₅
• 分子量: 263.25
• 闪点: 357.0±31.5 °C
• 精确质量: 263.079376
• PSA: 85.60000
• LogP: -0.94
• 蒸汽压: 0.0±4.6 mmHg at 25°C
• 折射率: 1.637
• 储存条件: 2-8°C，干燥密封

生物活性

• 描述: Exatecan中间体1(化合物6)是Exatecan(DX-8951、HY-13631)的中间体。Exatecan是一种抗癌剂,属于喜树碱类似物类。Exatecan通过与DNA相互作用干扰肿瘤细胞的增殖和分裂,从而抑制肿瘤生长。Exatecan主要用于研究多种癌症,包括卵巢癌、肺癌和乳腺癌[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素
• 参考文献:

  [1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.

  [2]. Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31.

安全

• 海关编码: 2934999090

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%