211513-37-0

• 常用中文名：CETP抑制剂
• 常用英文名：Dalcetrapib
• CAS号：211513-37-0
• 分子式：C₂₃H₃₅NO₂S
• 分子量：389.59500
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) CETP 抑制剂
• 发布时间：2018-08-03 18:25:20
• 更新时间：2026-07-01 17:55:28
• Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。

名称

• 中文名: 达塞曲匹
• 英文名: Dalcetrapib
• 中文别名: 达塞曲匹(CETP抑制剂); S-(2-(1-(2-乙基丁基)环己烷酰胺基)苯基)2-甲基丙硫酸酯; 达塞曲匹,10 MM DMSO 溶液; JTT-705 (Dalcetrapib) 10mM * 1mL in DMSO试剂; RHCETP抑制剂(DALCETRAPIB)
• 英文别名: JTT-705; Thioisobutyric acid S-(2-{[1-(2-ethyl-butyl)-cyclohexanecbonyl]-amino}-phenyl) ester; Dalcetrapib, 10 mM in DMSO; S-[2-({[1-(2-Ethylbutyl)cyclohexyl]carbonyl}amino)phenyl] 2-methylpropanethioate; S-[2-[[1-(2-ethylbutyl)cyclohexanecbonyl]amino]phenyl] 2-methylpropanethioate; Dalcetrapib(JTT-705),JTT705; S-(2-(1-(2-Ethylbutyl)cyclohexane-1-cboxamido)phenyl) 2-methylpropanethioate; S-2-(1-(2-ethylbutyl)cyclohexanecboxamido)phenyl 2-methylpropanethioate; Dalcetrapib(JTT-705); 2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcboxamido]phenyl] ester Dalcetrapib (JTT-705, RO4607381); Dalcetrapib (JTT-705, RO4607381); JTT-705 (Dalcetrapib); JTT-705 //BP; Propanethioic acid, 2-methyl-, S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl] ester; Unii-3D050liq3h; 2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcboxamido]phenyl] ester; RO4607381; EZSolution Dalcetrapib; JTT705;JTT; Dalcetrapib 2-Methylpropanethioic acid S-[2-[1-(2-ethylbutyl)cyclohexylcboxamido]phenyl] ester

物化性质

• 密度: 1.066 g/cm3
• 沸点: 528.912ºC at 760 mmHg
• 分子式: C₂₃H₃₅NO₂S
• 分子量: 389.59500
• 闪点: 273.676ºC
• 精确质量: 389.23900
• PSA: 71.47000
• LogP: 6.74960
• 储存条件: 室温，干燥，密封

生物活性

• 描述: Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> CETP
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454.

  [2]. Shinkai H, et al. J Med Chem. bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. 2000, 43(19), 3566-3572.

  [3]. Huang Z, et al. Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells. Am J Physiol Endocrinol Metab. 2003, 284(6), E1210-E1219.

安全

• 危害码 (欧洲): Xi