CETP抑制剂

• 常用名: CETP抑制剂
• 英文名: Dalcetrapib
• CAS号: 211513-37-0
• 分子量: 389.59500
• 密度: 1.066 g/cm3
• 沸点: 528.912ºC at 760 mmHg
• 分子式: C₂₃H₃₅NO₂S
• 熔点: N/A
• 闪点: 273.676ºC

CETP抑制剂用途

Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。

CETP抑制剂名称

• 中文名: 达塞曲匹
• 英文名: Dalcetrapib
• 中文别名: CETP抑制剂

CETP抑制剂生物活性

• 描述: Dalcetrapib (JTT-705; RO-4607381)是rhCETP抑制剂,IC50为0.2 μM,能增加血浆中HDL胆固醇。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> CETP
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Niesor EJ, et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport. J Lipid Res. 2010, 51(12), 3443-3454.

  [2]. Shinkai H, et al. J Med Chem. bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. 2000, 43(19), 3566-3572.

  [3]. Huang Z, et al. Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells. Am J Physiol Endocrinol Metab. 2003, 284(6), E1210-E1219.

CETP抑制剂物理化学性质

• 密度: 1.066 g/cm3
• 沸点: 528.912ºC at 760 mmHg
• 分子式: C₂₃H₃₅NO₂S
• 分子量: 389.59500
• 闪点: 273.676ºC
• 精确质量: 389.23900
• PSA: 71.47000
• LogP: 6.74960
• InChIKey: YZQLWPMZQVHJED-UHFFFAOYSA-N
• SMILES: CCC(CC)CC1(C(=O)Nc2ccccc2SC(=O)C(C)C)CCCCC1
• 储存条件: 室温，干燥，密封

CETP抑制剂安全信息

• 危害码 (欧洲): Xi

CETP抑制剂靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Decrease in aortic arch lesions in cholesterol fed rabbit 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL926256

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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CETP抑制剂英文别名

• JTT-705
• Unii-3D050liq3h
• S-[2-({[1-(2-Ethylbutyl)cyclohexyl]carbonyl}amino)phenyl] 2-methylpropanethioate
• Dalcetrapib
• Propanethioic acid, 2-methyl-, S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl] ester