178307-42-1

• 常用中文名：盐酸瑞伐拉赞
• 常用英文名：Revaprazan Hydrochloride
• CAS号：178307-42-1
• 分子式：C₂₂H₂₄ClFN₄
• 分子量：398.904
• 相关类别： 原料药 消化系统用药 抑制胃酸分泌药
• 发布时间：2018-06-19 22:53:05
• 更新时间：2026-07-06 15:19:45
• Revaprazan hydrochloride 是一种新型酸泵拮抗剂 (APA)。 Revaprazan hydrochloride 可降低 COX-2 的表达,并在幽门螺杆菌感染中具有显着的抗炎作用。

名称

• 中文名: 盐酸瑞伐拉赞
• 英文名: Revaprazan Hydrochloride
• 中文别名: 盐酸瑞伐拉赞,10 MM DMSO 溶液; 化合物：Revaprazan hydrochloride; 盐酸瑞伐拉赞杂质; 化合物:Revaprazan hydrochloride; 盐酸雷瓦拉沙; 瑞伐拉赞杂质; 盐酸洛氟普啶(盐酸瑞伐拉赞); 盐酸REVAPRAZAN; 酸瑞伐拉赞; 5,6-二甲基-2-(4-氟苯胺基)-4-(1-甲基-1,2,3,4-四氢异喹啉)嘧啶盐酸盐; 盐酸洛氟普啶; N-(4-氟苯基)-4,5-二甲基-6-(1-甲基-3,4-二氢异喹啉-2(1H)-基)嘧啶-2-胺盐酸盐; Revaprazan Hydrochloride :盐酸瑞伐拉赞; 瑞伐拉赞
• 英文别名: 4-(3,4-Dihydro-1-(Methyl-d3)-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-diMethyl-2-pyriMidinaMine Hydrochloride; Revaprzan hydrochloride; 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE; Like hydrochloride Swiss Vala; Revaprazan HCL //BP; N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-2(1H)-isoquinolinyl)-2-pyrimidinamine hydrochloride (1:1); SB 641257 Hydrochloride; Revaprazan HCl - Bio-X; Revaprazan hydrochloride, 10 mM in DMSO; 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE //BP; 2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, monohydrochloride; 4-(3,4-Dihydro-1-Methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-diMethyl-2-pyriMidinaMine Hydrochloride; SB 641257 Hydrochloride-d3; YH1885; N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine HCl; T66 CNT&J B1 C- DT6N CNJ BMR DF& E1 F1 &&HCl; 5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride; 4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine, monohydrochloride; SB 641257A-d3; 5,6-DiMethyl-2-(4-fluorophenylaMino)-4-(1-Methyl-d3 1,2,3,4-tetrahydroisoquinolin-2-yl)pyriMidine hydrochloride; N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine hydrochloride; Revanex; Revaprazan hydrochloride5; Revaprazan hydrochloride; Revaprazan HCL; SB 641257 HCl; YH 1885-d3; 2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, hydrochloride (1:1); SB 641257A

物化性质

• 熔点: 205-208°
• 分子式: C₂₂H₂₄ClFN₄
• 分子量: 398.904
• 精确质量: 398.167358
• PSA: 41.05000
• LogP: 6.03980
• 储存条件: 2-8°C

生物活性

• 描述: Revaprazan hydrochloride 是一种新型酸泵拮抗剂 (APA)。 Revaprazan hydrochloride 可降低 COX-2 的表达,并在幽门螺杆菌感染中具有显着的抗炎作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 免疫及炎症 >> COX
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Acid pump; COX-2[1]

• 参考文献:

  [1]. Lee JS, et al. Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.