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58-73-1生产厂家

58-73-1价格

相关CAS号：
58-73-1 13358-73-1
170082-18-5 147-24-0
8052-21-9 88637-37-0
341-69-5 1808-12-4
1219795-16-0 4682-36-4

58-73-1

58-73-1结构式
58-73-1结构式
  • 常用中文名：苯海拉明
  • 常用英文名：diphenhydramine
  • CAS号：58-73-1
  • 分子式：C17H21NO
  • 分子量：255.355
  • 相关类别： 有机原料 羧酸类化合物及衍生物 羧酸酰卤化物
  • 发布时间：2018-02-06 08:00:00
  • 更新时间：2024-01-02 14:04:14
  • 【用途一】
    用于皮肤粘膜的过敏性疾病及乘船乘车引起的恶心呕吐等。
    【用途二】
    该品与盐酸成盐，制成苯海拉明盐酸盐，是《国家基本药物》中选列的抗组织胺类药的一种。能降低组织对机体的反应，消除各种过敏症状，具有较强的中枢神经抑制作用和轻度的镇静及镇吐作用。用于荨麻疹、枯草热、血管神经性水肿、血清病、接触性皮炎、过敏性结膜炎。可防止晕动病，如晕船、晕车、孕期呕吐和震颤性麻痹等。

化源商城直购

中文名 苯海拉明
英文名 diphenhydramine
中文别名 2-(二苯甲氧基)-N,N-二甲基乙胺
N,N-二甲基-2-(二苯甲氧基)乙胺
二甲氨基乙醇二苯甲醚
英文别名 2-benzhydryloxy-N,N-dimethylethanamine
Antamin
b-Dimethylaminoethyl Benzhydryl Ether
EINECS 200-396-7
Cetamin
DPH (VAN)
Diphenhydramine Base
MFCD00274173
2-Diphenylmethoxy-N,N-dimethylethanamine
2-(Diphenylmethoxy)-N,N-dimethylethanamine
N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE
a-(2-Dimethylaminoethoxy)diphenylmethane
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-
Benzhydramine
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine
Dibendrin
DPH
diphenhydramine
描述 苯海拉明是第一代具有抗胆碱能作用的组胺H1受体拮抗剂。盐酸苯海拉明可以跨越绵羊血脑屏障[1][2]。
相关类别
参考文献

[1]. Jason P Berninger, et al. Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem. 2011 Sep;30(9):2065-72.
密度 1.0±0.1 g/cm3
沸点 343.7±27.0 °C at 760 mmHg
熔点 167-172°C
分子式 C17H21NO
分子量 255.355
闪点 101.5±26.0 °C
精确质量 255.162308
PSA 12.47000
LogP 3.66
外观性状 透明淡黄色液体
蒸汽压 0.0±0.8 mmHg at 25°C
折射率 1.551
储存条件 通风低温干燥,与库房食品原料分开存放
分子结构

1、 摩尔折射率：79.56

2、 摩尔体积（cm3/mol）：249.2

3、 等张比容（90.2K）：621.4

4、 表面张力（dyne/cm）：38.6

5、 极化率（10-24cm3）：31.54
计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:2

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积12.5

7.重原子数量:19

8.表面电荷:0

9.复杂度:211

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1
更多

1.性状：油状液体。

2.沸点（℃）：163-167（0.40kPa），150-165℃（0.267kPa）。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KR6825000
CHEMICAL NAME :
Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-
CAS REGISTRY NUMBER :
58-73-1
BEILSTEIN REFERENCE NO. :
1914136
LAST UPDATED :
199806
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C17-H21-N-O
MOLECULAR WEIGHT :
255.39
WISWESSER LINE NOTATION :
1N1&2OYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
714 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
7353 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Multiple routes
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
793 ug/kg/1H-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - ataxia Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
390 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
474 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
440 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
440 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
240 mg/kg
SEX/DURATION :
female 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
20 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Fibroblast
DOSE/DURATION :
100 mg/L
REFERENCE :
ACYTAN Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1- 1957- Volume(issue)/page/year: 16,41,1972 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5089 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 679 (estimated) No. of Female Employees: 370 (estimated)

危害码 (欧洲) Xi
海关编码 2922199090
【方法一】
由双苯甲醇（[91-01-0]）经氯乙醇醚化、与二甲胺缩合而得。
海关编码 2922199090
中文概述 2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

【58-73-1】化源网提供CAS号/CAS登录号58-73-1，CAS No.:58-73-1的msds、结构式、性质、英文名、生产厂家、作用/用途、分子式/化学式、密度、沸点、熔点等。CAS号查询58-73-1上化源网，专业又轻松。
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