849-55-8

• 常用中文名：Nylidrin Hydrochloride
• 常用英文名：Nylidrin hydrochloride
• CAS号：849-55-8
• 分子式：C₁₉H₂₆ClNO₂
• 分子量：335.86800
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-05-27 08:00:00
• 更新时间：2026-07-28 20:17:41
• Nylidrin hydrochloride 是被动致敏大鼠腹腔肥大细胞中IgE介导的组胺释放抑制剂，具有抗过敏的功效。

名称

• 中文名: 布芬宁盐酸盐
• 英文名: nylidrin hydrochloride
• 中文别名: 布芬宁盐酸盐,10 MM DMSO 溶液; 盐酸奈利德林; 盐酸布芬宁 标准品; NYLIDRIN盐酸盐; 盐酸布酚宁; 布酚宁盐酸盐
• 英文别名: Buphenin hydrochloride; Nylidrin Hydrochloride; Tocodilydrin; Dilatol; Dilydrin; Opino; libide; MFCD00035085; arlidinhydrochloride; Tocodrin; bupheninehydrochloride; nylidrine hydrochloride; NYLIDRIN HYDROCHLORIDE B-ADRENERGIC AGON IST; lidin; Buphenine,inhibit,Nylidrin,Inhibitor,Nylidrin hydrochloride; Nylidrin,HCl; Nylidrin hydrochloride, 10 mM in DMSO; Arlidin; Nylidrine hydrochloride; Rydrin; Buphenine HCl; Nylidrin HydrochlorideQ: What is Nylidrin Hydrochloride Q: What is the CAS Number of Nylidrin Hydrochloride Q: What is the storage condition of Nylidrin Hydrochloride; Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-,hydrochloride (1:1); Dilatropon; EINECS 212-701-0; Arlibide; p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd; dilatolhydrochloride; SKF 1700A; 1-p-hydroxyphenyl-2-(1’-methyl-3’-phenylpropylamino)-1-propanolhydrochloride; suprifenpsbhydrochloride; RHC 3432A; p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzylalcoholhydro; Dilatal; Rudilin; Benzyl alcohol, p-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride; Buphenin Hydrochloride (Mixture of DiastereoMers); p-Hydroxy-alpha-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl alcohol hydrochloride; Buphedrin; Benzenemethanol, 4-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride; dilatyl; Penitdon; lidinhydrochloride; Nylidrin, HCl; Perdilatal; Verina

物化性质

• 熔点: 111ºC
• 分子式: C₁₉H₂₆ClNO₂
• 分子量: 335.86800
• 精确质量: 335.16500
• PSA: 52.49000
• LogP: 4.61790
• 外观性状: 粉末
• 储存条件: -20℃
• 计算化学:

  1、 氢键供体数量：4

  2、 氢键受体数量：3

  3、 可旋转化学键数量：2

  4、 互变异构体数量：7

  5、 拓扑分子极性表面积（TPSA）：52.5

  6、 重原子数量：23

  7、 表面电荷：0

  8、 复杂度：296

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：3

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Nylidrin hydrochloride 是被动致敏大鼠腹腔肥大细胞中IgE介导的组胺释放抑制剂,具有抗过敏的功效。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4)

毒性和生态

毒理学数据: 1、急性毒性：小鼠口经LD50：250mg/kg；大鼠口经LD50：>4800mg/kg 2、急性毒性：小鼠腹腔LD50：136mg/kg；大鼠腹腔LD50：380mg/kg 3、急性毒性：小鼠静脉LD50：40mg/kg；大鼠LD50：37400ug/kg CHEMICAL IDENTIFICATION RTECS NUMBER : DO8300000 CHEMICAL NAME : Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)et hyl)-, hydrochloride CAS REGISTRY NUMBER : 849-55-8 LAST UPDATED : 199504 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H25-N-O2.Cl-H MOLECULAR WEIGHT : 335.91 WISWESSER LINE NOTATION : QR DYQY1&MY1&2R &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,538,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3542870 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 136 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 24,431,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,351,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6178 No. of Facilities: 36 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 357 (estimated) No. of Female Employees: 187 (estimated)

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 20/21/22
• 安全声明 (欧洲): 36
• WGK德国: 3
• RTECS号: DO8300000