199739-10-1

• 常用中文名：帕潘立酮棕榈酸酯
• 常用英文名：Paliperidone Palmitate
• CAS号：199739-10-1
• 分子式：C₃₉H₅₇FN₄O₄
• 分子量：664.893
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-02-18 08:00:00
• 更新时间：2026-07-05 17:44:24
• Paliperidone palmitate (9-Hydroxyrisperidone palmitate) 是一种非典型长效抗精神病药,是 Paliperidone 的酯类前药。Paliperidone 是一种非典型抗精神病药的多巴胺 (dopamine) 拮抗剂和 5-HT2A 拮抗剂。Paliperidone palmitate 对精神分裂症有效。

名称

• 中文名: 帕潘立酮棕榈酸酯
• 英文名: [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] hexadecanoate
• 中文别名: 帕利哌酮棕榈酸酯; 棕榈酸帕潘立酮; 帕潘立酮杂质D31; 帕潘立酮棕榈酸酯-D31; 棕榈酸帕利哌酮; 帕潘立酮棕榈酸酯/帕利哌酮棕榈酸酯; 棕榈酸帕立哌酮; 卡博特韦中1; 3-(2-(4-(6-氟苯并[D]异恶唑-3-基)哌啶-1-基)乙基)-2-甲基-4-氧代-6,7,8,9-四氢-4H-吡啶并[1,2-A]嘧啶-9-基棕榈酸酯; 棕榈酸帕利哌酮杂质; 3-(2-(4-(6-氟苯并[d]异噁唑-3-基)哌啶-1-基)乙基)-2-甲基-4-氧代-6,7,8,9-四氢-4H-吡啶并[1,2-a]嘧啶-9-基 棕榈酸酯; 帕潘立酮棕榈酸酯PALIPERIDONE PALMITATE [USAN]; 帕立哌酮棕榈酸酯; 帕潘利酮棕榈酸酯; 棕榈酸帕利哌酮杂质2; 棕榈酸帕利哌酮杂质1; 棕榈酸帕利哌酮杂质4; 棕榈酸帕利哌酮(A045); 棕榈酸帕利哌酮杂质3; 帕潘立酮杂质39(棕榈酸帕利哌酮); Paliperidone Palmitate :棕榈酸帕利哌酮; 棕榈酸帕利哌酮杂质6; 棕榈酸帕利哌酮杂质5; 帕潘立酮棕榈酸盐
• 英文别名: (9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)et hyl)-2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyriMi din-9-yl hexadecanoate; Palmitic acid paliperidone standd; Xeplion; 3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate; Hexadecanoic acid 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester; Paliperidone Palmitate Benzisoxazole Impurity; Paliperidone Impurity: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester; 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido-[1,2-a]pyrimidin-4-one palmitate ester; Paliperidone Palmitate-d31; PALPERIDONE PALMITATE; Invega Sustenna; Palmitone Palmitate Impurity 2; Paliperidone Palmitate [USAN]; Palmitone Palmitate Impurity 3; Palmitone Palmitate Impurity 4; 3-[2-[4-(6-fluoro-1,2-benzoisoxazol-3-yl)-1-piperidyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one palmitate ester; Palmitone Palmitate Impurity 5; Palmitone Palmitate Impurity 6; Palmitic acid paliperidone impurity; Paliperidone palmitateQ: What is Paliperidone palmitate Q: What is the CAS Number of Paliperidone palmitate Q: What is the storage condition of Paliperidone palmitate Q: What e the applications of Paliperidone palmitate; 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate; 9-Hydroxyrisperidone palmitate; Palmitic acid paliperidone impurity 5; Paliperidone Impurity 39 (Paliperidone Palmitate); Palmitic acid paliperidone impurity 1; Palmitic acid paliperidone impurity 2; Palmitic acid paliperidone impurity 3; Palmitic acid paliperidone impurity 4; Hexadecanoic acid 3-[2-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester; Paliperidone Palmitate //BP; UNII-R8P8USM8FR; Hexadecanoic acid, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 736.3±70.0 °C at 760 mmHg
• 分子式: C₃₉H₅₇FN₄O₄
• 分子量: 664.893
• 闪点: 399.1±35.7 °C
• 精确质量: 664.436401
• PSA: 90.46000
• LogP: 9.85
• 外观性状: 粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.590
• 储存条件: -20℃

生物活性

• 描述: Paliperidone palmitate (9-Hydroxyrisperidone palmitate) 是一种非典型长效抗精神病药,是 Paliperidone 的酯类前药。Paliperidone 是一种非典型抗精神病药的多巴胺 (dopamine) 拮抗剂和 5-HT2A 拮抗剂。Paliperidone palmitate 对精神分裂症有效。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点:

  5-HT2A Receptor

  D2 Receptor

• 参考文献:

  [1]. Kwon JS, et al. Satisfaction of immediate or delayed switch to paliperidone palmitate in patients unsatisfied with current oral atypical antipsychotics. Int Clin Psychopharmacol. 2015;30(6):320-328.

合成路线

1415488-05-9 84163-13-3 ~77% 199739-10-1

文献：WO2012/164582 A1, ; Page/Page column 11-12 ;

623-65-4 144598-75-4 ~90% 199739-10-1

文献：WO2009/89076 A2, ; Page/Page column 15; 29 ;

57-10-3 144598-75-4 ~81% 199739-10-1

文献：WO2009/89076 A2, ; Page/Page column 28 ;

144598-75-4 112-67-4 ~55% 199739-10-1

文献：WO2009/89076 A2, ; Page/Page column 25-26 ;

1172995-09-3 112-67-4 ~10% 199739-10-1

文献：WO2009/89076 A2, ; Page/Page column 9; 26 ;

57-10-3 ~% 199739-10-1

文献：WO2012/164582 A1, ;

130049-82-0 ~% 199739-10-1

文献：WO2012/164582 A1, ;

上下游产品

上游产品  6
84163-13-3 623-65-4 144598-75-4 57-10-3
112-67-4 130049-82-0
下游产品  1
144598-75-4