98774-23-3

• 常用中文名：替米利芬
• 常用英文名：Tesmilifene
• CAS号：98774-23-3
• 分子式：C₁₉H₂₅NO
• 分子量：283.408
• 相关类别： 原料药 抗寄生虫病药 抗疟药
• 发布时间：2018-07-18 19:47:07
• 更新时间：2026-07-01 18:26:04
• Tesmilifene is a novel agent that augments cytotoxicity of various chemotherapeutic agents both in vitro and in vivo. It binds selectively to the high-affinity microsomal antiestrogen binding site (Ki=50nm) but has no affinity for estrogen receptors. Inhi

名称

• 中文名: 替米利芬
• 英文名: Tesmilifene
• 中文别名: N,N-二乙基-2-(4-苄基苯氧基)乙胺; 2-(4-苄基苯氧基)-N,N-二乙胺; 帕托珠利
• 英文别名: DPPE; Unii-I43T3id6G2; UNII-I43T3ID6G2; Ethanamine, N,N-diethyl-2-(4-(phenylmethyl)phenoxy); Tesmilifine; Mquis; 92-7 (Hydrochloride); TESMILIFENE; Patozuli 98-3; 2-[(a-Phenyl-p-tolyl)oxy]triethylamine; N,N-Diethyl-2-(4-benzylphenoxy)ethanamine; (2-(4-benzylphenoxy)ethyl)diethylamine; Tesmilifene //BP; 2-(4-benzylphenoxy)-N,N-diethyl-ethanamine; Pato bead; tesmilifene; 2-(4-Benzylphenoxy)-N,N-diethylethanamine; Dmpe; Depmpe

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 397.0±30.0 °C at 760 mmHg
• 分子式: C₁₉H₂₅NO
• 分子量: 283.408
• 闪点: 116.8±26.9 °C
• 精确质量: 283.193604
• PSA: 12.47000
• LogP: 5.04
• 外观性状: 透明,无色液体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.543

合成路线

101-53-1 869-24-9 ~% 98774-23-3

文献：Journal of Medicinal Chemistry, , vol. 43, # 4 p. 721 - 735

100-35-6 ~% 98774-23-3

文献：Rev. Asoc. bioquim. arg., , vol. 20, p. 7,12 Rev. Fac. Cienc. quim. Univ. La Plata, , vol. 22, p. 143,147