204656-20-2

• 常用中文名：利拉鲁肽
• 常用英文名：Liraglutide
• CAS号：204656-20-2
• 分子式：C₁₇₂H₂₆₅N₄₃O₅₁
• 分子量：3751.20000
• 相关类别： 原料药 激素及调节内分泌功能类药 胰腺激素及其它调节血糖药
• 发布时间：2018-05-10 08:00:00
• 更新时间：2026-07-01 06:38:36
• Liraglutide 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂,用于治疗 2 型糖尿病。

名称

• 中文名: 利拉鲁肽
• 英文名: liraglutide
• 中文别名: LIRAGLUTIDE[干冰运输; 利拉鲁肽-D8三氟乙酸; 利拉鲁肽 Liraglutide; Liraglutide/利拉鲁肽; 利拉鲁肽/醋酸利拉鲁肽; 醋酸利拉鲁肽; 化合物：Liraglutide; 醋酸利拉鲁; 利拉鲁肽原料; 抑制剂Liraglutide; LIRAGLUTIDE 利拉鲁肽; Liraglutide试剂; 利拉鲁肽(钠盐); LIRAGLUTIDE,GLUCAGON-LIKE多肽-1(GLP-1) RECTOR激动剂; 利拉鲁肽-D8 三氟乙酸酯; 利拉鲁肽杂质; 化合物:Liraglutide; 利拉糖肽; 醋酸利拉鲁肽(GLP-1变体); 利拉鲁肽试剂原料
• 英文别名: Liraglutide /Liraglutide Acetate; (Lys(γ-Glu-palmitoyl)26,g34)-GLP-1; Liraglutidum [inn-latin]; (4S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S; Liaglutide; Liraglutide, (Lys(γ-Glu-palmitoyl)26,g34)-GLP-1; ade Liraglutide; Liraglutide //BP; Glycine, L-histidyl-L; Liraglutide GLP-1; Liraglutide, glucagon-like ptide-1(GLP-1) rector agonist; Liraglutide [usan:inn]; Liraglutide-d8 Tri-TrifluoroacetateQ: What is Liraglutide-d8 Tri-Trifluoroacetate Q: What is the CAS Number of Liraglutide-d8 Tri-Trifluoroacetate Q: What is the storage condition of Liraglutide-d8 Tri-Trifluoroacetate; Liraglutide injection; Liraglutide Acetate; Liraglutide-d8 Tri-Trifluoroacetate; Liraglutidum; (4S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-5-hyd; Liraglutida [inn-spanish]; Liraglutidec; g34 GLP-1-OH; High Purity Liraglutide; inhibit,Liraglutide,Glucagon Rector,Inhibitor; Liraglutide, NN2211; LiraglutideQ: What is Liraglutide Q: What is the CAS Number of Liraglutide Q: What is the storage condition of Liraglutide Q: What e the applications of Liraglutide; H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(g-Glu-palMitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-g-Gly-g-Gly-OH; N26-(Hexadecanoyl-gamma-glutamyle)-(34-ginine)glp-1-ptide; Lose Weight Ptides Liraglutide; Liraglutide Impurity; HAEGTFTSDVSSYLEGQAAK [N-(1-oxohexadecyl)-L-γ-glutaMyl] EFI AWLVRG; N26-(Hexadecanoyl-gamma-glutamyle)-(34-ginine)glucagon-like-ptide-1-ptide; Liraglutida; (Lys(γ-Glu-palMitoyl)26,g34)-GLP-1 Liraglutide, NN2211; Liroglutide; The lalu ptide; Glycine, L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-asptyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-(N-(1-oxohexadecyl)-L-gamma-glutamyl)-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-ginylglycyl-L-ginyl; Liraglutide (sodium salt); NNC 0; Liraglutide D4Q: What is Liraglutide D4 Q: What is the CAS Number of Liraglutide D4 Q: What is the storage condition of Liraglutide D4 Q: What e the applications of Liraglutide D4; Victoza; (Lys(g-Glu-palMitoyl)26,g34)-GLP-1

物化性质

• 分子式: C₁₇₂H₂₆₅N₄₃O₅₁
• 分子量: 3751.20000
• 精确质量: 3748.95000
• PSA: 1513.76000
• LogP: 6.12960
• 储存条件: -20°C

生物活性

• 描述: Liraglutide 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂,用于治疗 2 型糖尿病。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体
  研究领域 >> 代谢疾病
  多肽产品
  多肽产品
• 靶点:

  GLP-1 receptor[1]

• 体外研究: 利拉鲁肽与刺激胰岛素分泌的内源性代谢激素GLP-1结合相同的受体。利拉鲁肽是一种用于治疗2型糖尿病的注射药物,也可用于治疗患有某些相关合并症的成人肥胖症。利拉鲁肽在oxLDL刺激的Raw264.7细胞中激活AMPK/SREBP1途径[1]。
• 细胞实验: 将Raw264.7巨噬细胞在补充有10％胎牛血清的Dulbecco改良的Eagle培养基中在含有5％CO 2的潮湿37℃培养箱中培养。将细胞与oxLDL（50μg/ mL），利拉鲁肽（0.1,0.5,1和2nM）或Exendin-3（9-39）（1,10和100nM）单独或组合[1]一起温育。
• 参考文献:

  [1]. Wang Y,et al. Transformation of oligomers of lipidated peptide induced by change in pH.Mol Pharm. 2015 Feb 2;12(2):411-9.

  [2]. Wang YG, et al. Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.J Geriatr Cardiol. 2015 Jul;12(4):410-416.