36167-63-2

• 常用中文名：盐酸卤泛群
• 常用英文名：Halofantrine hydrochloride
• CAS号：36167-63-2
• 分子式：C₂₆H₃₁Cl₃F₃NO
• 分子量：536.885
• 相关类别： 原料药 抗寄生虫病药 抗疟药
• 发布时间：2018-04-27 08:00:00
• 更新时间：2024-01-03 15:54:37
• Halofantrine hydrochloride (SKF-102886)是一种通过抑制人ERG通道 来延迟整流钾电流的阻滞剂,是一种有效的抗疟疾药。

名称

• 中文名: 盐酸卤泛群
• 英文名: Halofantrine Hydrochloride
• 中文别名: 卤泛群 盐酸盐
• 英文别名: 9-phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride; UNII:2B7ENL644K; 3-(Dibutylamino)-1-[1,3-dichlor-6-(trifluormethyl)phenanthren-9-yl]propan-1-olhydrochlorid; MFCD00879136; 3-(Dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthryl]propan-1-ol hydrochloride (1:1); 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride; EINECS 252-895-4; 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride (1:1); 3-(Dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthryl]-1-propanol hydrochloride (1:1); 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride (1:1); Halofantrine hydrochloride; 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluorométhyl)phénanthrén-9-yl]propan-1-ol chlorhydrate; UNII:H77DL0Y630

物化性质

• 密度: 1.244g/cm3
• 沸点: 596.2ºC at 760mmHg
• 分子式: C₂₆H₃₁Cl₃F₃NO
• 分子量: 536.885
• 闪点: 314.4ºC
• 精确质量: 535.142334
• PSA: 23.47000
• LogP: 9.44630
• 储存条件: 2-8°C
• 分子结构:

  1、 摩尔折射率：131.67

  2、 摩尔体积（cm³/mol）：403.7

  3、 等张比容（90.2K）：1004.2

  4、 表面张力（dyne/cm）：38.2

  5、 极化率（10-24cm3）：52.19

生物活性

• 描述: Halofantrine hydrochloride (SKF-102886)是一种通过抑制人ERG通道 来延迟整流钾电流的阻滞剂,是一种有效的抗疟疾药。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 靶点:

  Malaria[1].HERG channel[2].

• 参考文献:

  [1]. Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec;36(6):585-91.

  [2]. Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000) Traebert.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SF7790000 CHEMICAL NAME : 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluo romethyl)-, hydrochloride CAS REGISTRY NUMBER : 36167-63-2 LAST UPDATED : 199503 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C26-H30-Cl2-F3-N-O.Cl-H MOLECULAR WEIGHT : 536.93 WISWESSER LINE NOTATION : L B666J DG FG IYQ2N4&4 MXFFF &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 7143 ug/kg TOXIC EFFECTS : Liver - liver function tests impaired Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - hematuria REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 340,909,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 18 mg/kg/D TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Gastrointestinal - other changes REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 5,547,1980 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 72 mg/kg/3D-I TOXIC EFFECTS : Cardiac - cardiomyopathy including infarction REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,1054,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 7143 ug/kg TOXIC EFFECTS : Liver - jaundice, other or unclassified Kidney, Ureter, Bladder - urine volume decreased Blood - other hemolysis with or without anemia REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 340,909,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3400 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2050 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 240 mg/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,85,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 120 mg/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,85,1984

安全

• 危害声明: H413
• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• RTECS号: SF7790000