盐酸卤泛群结构式
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常用名 | 盐酸卤泛群 | 英文名 | Halofantrine hydrochloride |
|---|---|---|---|---|
| CAS号 | 36167-63-2 | 分子量 | 536.885 | |
| 密度 | 1.244g/cm3 | 沸点 | 596.2ºC at 760mmHg | |
| 分子式 | C26H31Cl3F3NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 314.4ºC |
盐酸卤泛群用途Halofantrine hydrochloride (SKF-102886)是一种通过抑制人ERG通道 来延迟整流钾电流的阻滞剂,是一种有效的抗疟疾药。 |
| 中文名 | 盐酸卤泛群 |
|---|---|
| 英文名 | Halofantrine Hydrochloride |
| 中文别名 | 卤泛群 盐酸盐 |
| 英文别名 | 更多 |
| 描述 | Halofantrine hydrochloride (SKF-102886)是一种通过抑制人ERG通道 来延迟整流钾电流的阻滞剂,是一种有效的抗疟疾药。 |
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| 相关类别 | |
| 靶点 |
Malaria[1].HERG channel[2]. |
| 参考文献 |
| 密度 | 1.244g/cm3 |
|---|---|
| 沸点 | 596.2ºC at 760mmHg |
| 分子式 | C26H31Cl3F3NO |
| 分子量 | 536.885 |
| 闪点 | 314.4ºC |
| 精确质量 | 535.142334 |
| PSA | 23.47000 |
| LogP | 9.44630 |
| 储存条件 | 2-8°C |
| 分子结构 | 1、 摩尔折射率：131.67 2、 摩尔体积（cm3/mol）：403.7 3、 等张比容（90.2K）：1004.2 4、 表面张力（dyne/cm）：38.2 5、 极化率（10-24cm3）：52.19 |
| 危害声明 | H413 |
|---|---|
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| 危险品运输编码 | NONH for all modes of transport |
| RTECS号 | SF7790000 |
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Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Chirality 24(7) , 558-65, (2012) Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The pres... |
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Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.
Antimicrob. Agents Chemother. 56(3) , 1382-9, (2012) Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700... |
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Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
Eur. J. Pharm. Sci. 47(2) , 347-51, (2012) The purpose of this study was to evaluate if a rat model, based upon co-administration of the anion-exchanging resin, cholestyramine, could replace surgery when evaluating the importance of bile on dr... |
| 9-phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride |
| UNII:2B7ENL644K |
| 3-(Dibutylamino)-1-[1,3-dichlor-6-(trifluormethyl)phenanthren-9-yl]propan-1-olhydrochlorid |
| MFCD00879136 |
| 3-(Dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthryl]propan-1-ol hydrochloride (1:1) |
| 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride |
| EINECS 252-895-4 |
| 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride (1:1) |
| 3-(Dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthryl]-1-propanol hydrochloride (1:1) |
| 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, hydrochloride (1:1) |
| Halofantrine hydrochloride |
| 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluorométhyl)phénanthrén-9-yl]propan-1-ol chlorhydrate |
| UNII:H77DL0Y630 |
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