4812-40-2

• 常用中文名：羟基甲硝唑
• 常用英文名：Hydroxymetronidazole
• CAS号：4812-40-2
• 分子式：C₆H₉N₃O₄
• 分子量：187.15300
• 相关类别： 分析化学 标准品 生命科学标准品
• 发布时间：2018-03-08 08:00:00
• 更新时间：2026-07-01 00:20:15
• Hydroxymetronidazole (Metronidazole-OH) 是一种 Metronidazole 的代谢产物,属于硝基咪唑类。Hydroxymetronidazole 可用于研究家禽中的某些细菌和原生动物疾病,以及牛痢疾和牛生殖器滴虫病。

名称

• 中文名: 羟基甲硝唑
• 英文名: Hydroxy Metronidazole
• 中文别名: 甲硝唑-OH; 乙腈中羟基甲硝唑; 羟基甲硝唑-同位素; 羟基甲硝唑MNZOH; 1-(2-羟基乙基)-2-羟甲基-5-硝基咪唑; 甲硝唑杂质H; 羟基甲硝唑溶液, 100UG/ML 甲醇溶液; 羟基甲硝唑|Metronidazole-hydroxy; 甲醇中羟基甲硝唑溶液标准物质; 羟基甲硝唑溶液, 1000PPM; 羟基甲硝唑 标准品; 羟基甲硝唑溶液,100PPM; 1-(2-羟乙基)-2-羟甲基-5-硝基咪唑; 甲硝唑杂质H(自编); 甲硝唑杂质 标准品; 羟基甲硝唑标准品; 羟基甲硝唑溶液, 1000UG/ML 甲醇溶液
• 英文别名: 2-hydroxymethyl-5-nitro-imidazole-1-ethano; Metronidazole-hydroxy solution,1000ppm solution,100ppm; 1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole (Hydroxy; 2-[2-(hydroxymethyl)-5-nitroimidazol-1-yl]ethanol; HYDROXY METRONIDAZOLE; 4-Hydroxy-2-methyl-5-nitro-1H-imidazole-1-ethanol; MNZOH; Metronidazole Impurity H; 1-(2-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE; Metronidazole-hydroxy 100 μg/mL in Acetonitrile; Metronidazole-hydroxy solution,100ppm; Metronidazole-OH,1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole, Hydroxymetronidazole, MNZOH; Metronidazole-hydroxy 100 μg/ml Methanol; METRONIDAZOLE-OH; 1H-IMidazole-1-ethanol, 2-(hydroxyMethyl)-5-nitro; 1-(2-Hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole, Hydroxymetronidazole, MNZOH; Hydroxymetronidazole in acetonitrile; Metronidazole-hydroxy 100 μg/mL in Methanol; 1-(2-Hydroxyethyl)-2-hydroxymethyl; Metronidazole-OH MNZOH; Hydroxy Metronidazo; C15201300 Metronidazole-hydroxy; Hydroxy Metronidazole D2Q: What is Hydroxy Metronidazole D2 Q: What is the CAS Number of Hydroxy Metronidazole D2 Q: What is the storage condition of Hydroxy Metronidazole D2 Q: What e the applications of Hydroxy Metronidazole D2; 2-(HydroxyMethyl)-5-nitro; ROXYMETHYL-5-NITROIMIDAZOLE; MNZOH, Hydroxy metronidazole Solution, 100ppm; Hydroxy MetronidazoleQ: What is Hydroxy Metronidazole Q: What is the CAS Number of Hydroxy Metronidazole Q: What is the storage condition of Hydroxy Metronidazole Q: What e the applications of Hydroxy Metronidazole; Metronidazole-hydroxy

物化性质

• 密度: 1.61g/cm3
• 沸点: 475.2ºC at 760mmHg
• 熔点: 118-121ºC
• 分子式: C₆H₉N₃O₄
• 分子量: 187.15300
• 闪点: 241.2ºC
• 精确质量: 187.05900
• PSA: 104.10000
• 折射率: 1.643
• 储存条件: -20?C Freezer

生物活性

• 描述: Hydroxymetronidazole (Metronidazole-OH) 是一种 Metronidazole 的代谢产物,属于硝基咪唑类。Hydroxymetronidazole 可用于研究家禽中的某些细菌和原生动物疾病,以及牛痢疾和牛生殖器滴虫病。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Rodrigo H M M Granja, et al. Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):970-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI5568000 CHEMICAL NAME : Imidazole-1-ethanol, 2-hydroxymethyl-5-nitro- CAS REGISTRY NUMBER : 4812-40-2 BEILSTEIN REFERENCE NO. : 0883934 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C6-H9-N3-O4 MOLECULAR WEIGHT : 187.18 WISWESSER LINE NOTATION : T5N CNJ A2Q B1Q ENW HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Klebsiella pneumoniae DOSE/DURATION : 10 umol/L/20H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: NI5568000

合成路线

147124-51-4 ~77% 4812-40-2

文献：Hambalek; Just Synthetic Communications, 1993 , vol. 23, # 2 p. 209 - 215

147124-50-3 ~% 4812-40-2

文献：Hambalek; Just Synthetic Communications, 1993 , vol. 23, # 2 p. 209 - 215

147124-49-0 ~% 4812-40-2

文献：Hambalek; Just Synthetic Communications, 1993 , vol. 23, # 2 p. 209 - 215

1016-40-6 ~% 4812-40-2

文献：Hambalek; Just Synthetic Communications, 1993 , vol. 23, # 2 p. 209 - 215

上下游产品

上游产品  3
147124-51-4 147124-50-3 1016-40-6
下游产品  0