544467-07-4

544467-07-4结构式

常用中文名：HIV-1整合酶抑制剂
常用英文名：HIV-1 integrase inhibitor
CAS号：544467-07-4
分子式：C₁₁H₉N₃O₄
分子量：247.20700
相关类别：生物化工抑制剂微生物学(Microbiology) Integrase 抑制剂
发布时间：2016-02-21 16:52:18
更新时间：2025-08-26 10:56:58
HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。

中文名	4-[3-(叠氮基甲基)苯基]-2-羟基-4-氧代-2-丁烯酸
英文名	2-Butenoic acid, 4-[3-(azidomethyl)phenyl]-2-hydroxy-4-oxo
英文别名	HIV-1 integrase inhibitor

描述	HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶信号通路 >> 抗感染 >> HIV 研究领域 >> 感染
参考文献	[1]. Hobaika, Z.; Zargarian, L.; Maroun, R. G.; Mauffret, O.; Burke, T. R., Jr.; Fermandjian, S. HIV-1 Integrase and Virus and Cell DNAs: Complex Formation and Perturbation by Inhibitors of Integration. Neurochemical Research (2010), 35(6), 888-893. [2]. Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos; Kostrikis, Leondios G. Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance. Bioorganic & Medicinal Chemistry (2009), 17(13), 4806-4818. [3]. Kawasuji T.Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore.J Med Chem. 2012 Sep 10. [4]. Yan A, Xuan S, Hu X.Classification of Active and Weakly Active ST Inhibitors of HIV-1 Integrase Using a Support Vector Machine.Comb Chem High Throughput Screen. 2012 Aug 28. [5]. Yu S, Zhao G.Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.Curr Med Chem. 2012 Aug 27.