HIV-1整合酶抑制剂

更新时间：2025-08-26 10:56:58

HIV-1整合酶抑制剂结构式	常用名	HIV-1整合酶抑制剂	英文名	HIV-1 integrase inhibitor
	CAS号	544467-07-4	分子量	247.20700
	密度	N/A	沸点	N/A
	分子式	C₁₁H₉N₃O₄	熔点	N/A
	MSDS	N/A	闪点	N/A

HIV-1整合酶抑制剂用途

HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。

中文名	4-[3-(叠氮基甲基)苯基]-2-羟基-4-氧代-2-丁烯酸
英文名	2-Butenoic acid, 4-[3-(azidomethyl)phenyl]-2-hydroxy-4-oxo
英文别名	更多

描述	HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶信号通路 >> 抗感染 >> HIV 研究领域 >> 感染
参考文献	[1]. Hobaika, Z.; Zargarian, L.; Maroun, R. G.; Mauffret, O.; Burke, T. R., Jr.; Fermandjian, S. HIV-1 Integrase and Virus and Cell DNAs: Complex Formation and Perturbation by Inhibitors of Integration. Neurochemical Research (2010), 35(6), 888-893. [2]. Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos; Kostrikis, Leondios G. Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance. Bioorganic & Medicinal Chemistry (2009), 17(13), 4806-4818. [3]. Kawasuji T.Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore.J Med Chem. 2012 Sep 10. [4]. Yan A, Xuan S, Hu X.Classification of Active and Weakly Active ST Inhibitors of HIV-1 Integrase Using a Support Vector Machine.Comb Chem High Throughput Screen. 2012 Aug 28. [5]. Yu S, Zhao G.Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.Curr Med Chem. 2012 Aug 27.

描述

HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

参考文献

[1]. Hobaika, Z.; Zargarian, L.; Maroun, R. G.; Mauffret, O.; Burke, T. R., Jr.; Fermandjian, S. HIV-1 Integrase and Virus and Cell DNAs: Complex Formation and Perturbation by Inhibitors of Integration. Neurochemical Research (2010), 35(6), 888-893.

[2]. Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos; Kostrikis, Leondios G. Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance. Bioorganic & Medicinal Chemistry (2009), 17(13), 4806-4818.

[3]. Kawasuji T.Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore.J Med Chem. 2012 Sep 10.

[4]. Yan A, Xuan S, Hu X.Classification of Active and Weakly Active ST Inhibitors of HIV-1 Integrase Using a Support Vector Machine.Comb Chem High Throughput Screen. 2012 Aug 28.

[5]. Yu S, Zhao G.Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.Curr Med Chem. 2012 Aug 27.

分子式	C₁₁H₉N₃O₄
分子量	247.20700
精确质量	247.05900
PSA	124.35000
LogP	1.65886
储存条件	2-8℃

实验名称：NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C...
来源：NCGC
靶标：N/A
External Id：adst_HEK293_Anti-infectives-02

实验名称：NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
来源：NCGC
靶标：N/A
External Id：adst_Celegans_Anti-infectives-o1

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
来源：NCGC
External Id：APP-Toga-CHIKV-nsp2-p

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HIV-1 integrase inhibitor

HIV-1整合酶抑制剂

HIV-1整合酶抑制剂用途

HIV-1整合酶抑制剂名称

HIV-1整合酶抑制剂生物活性

HIV-1整合酶抑制剂物理化学性质

HIV-1整合酶抑制剂靶点实验

HIV-1整合酶抑制剂英文别名

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