123441-03-2

• 常用中文名：利凡斯的明
• 常用英文名：Rivastigmine
• CAS号：123441-03-2
• 分子式：C₁₄H₂₂N₂O₂
• 分子量：250.34
• 相关类别： 原料药 神经系统用药 脑代谢调节药
• 发布时间：2018-08-31 13:02:28
• 更新时间：2026-07-01 09:55:05
• Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。

名称

• 中文名: 利凡斯的明
• 英文名: rivastigmine
• 中文别名: (S)-卡巴拉汀; (S)-利伐斯的明; (S)-3-(1-(二甲基氨基)乙基)苯基乙基(甲基)氨基甲酸酯; 3-((S)-1-(二甲氨基)乙基)苯酯; 利瓦斯的明; 卡巴拉汀系统适应性 标准品; 卡巴拉汀碱; (S) -利凡斯的明; 利斯的明相关杂质; 卡巴拉汀,10 MM DMSO 溶液; 利伐斯的明; 利斯的明; 卡巴拉丁游离碱; 卡巴拉丁; 卡巴拉汀; 卡巴拉汀中间体,卡巴拉汀; 卡巴拉汀杂质11; N-乙基-N-甲基-氨基甲酸; 卡巴拉汀原料; 卡巴拉汀相关杂质; 卡巴拉汀单体; 纯度卡巴拉汀优势产品; N-乙基-N-甲基-氨基甲酸 3-[(S)-1-(二甲氨基)乙基]苯酯; 卡巴拉汀游离碱; 利瓦斯汀杂质; 利凡斯的明/卡巴拉汀; 卡巴拉汀杂质; 3-[(S)-1-(二甲氨基)乙基]苯酯; 卡巴拉汀 利凡斯的明; 卡巴拉汀(利斯的明)
• 英文别名: Rivastigmine for system suitability CRS; Rivastigmine (S-Rivastigmine); Ethylmethylcbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester; Rivastigmine //BP; Kabatin; Rivastigmine base; Unii-pki06m3iw0; 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate; RivastigiMine; S-RivastigMine; (S)-N-Ethyl-N-Methyl- 3-[1-(diMethylaMino)ethyl]- phenyl cbaMate; Revastigmine (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)cbamate; EXELON; Benzo[b]thiophene-2-cboxylicacid,3-chloro-5,10-dimethoxy-,methylester; Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; N-Ethyl-N-methylcbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester; Rivastigmine Impurity; (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate; Cbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S); Rivastigmine Base/ Ttrate; (S)-3-[1-(diMethylaMino)ethyl]phenyl N-ethyl-N-MethylcbaMate; CbaMic acid, N-ethyl-N-Methyl-, 3-[(1S)-1-(diMethylaMino)ethyl]phenyl ester; (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)cbamate; mine; RIVASTIGMINE; cabalatine; (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methylphenylcarbamate; RIVASTIGMINE HYDROGEN TTRATE; RIVASTIGIMINE(FORR&DONLY); carbamic acid, ethyl(methyl)-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; 3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcbamate; Cbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester; bis(sulfanylidene)ruthenium; 3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcbamate; Rivastigmine Monomer; [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate; MFCD03700731; Rivastigmine, 10 mM in DMSO; N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester; Rivastigmine (0.); Rivastig; Ena 713 free base; Ethylmethylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester; Rivastigmine intermediate,Rivastigmine; Revastigmine; 3-[(1S)-1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 316.2±34.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂N₂O₂
• 分子量: 250.34
• 闪点: 145.0±25.7 °C
• PSA: 147.84000
• LogP: 2.14
• 外观性状: 液体;Colorless to Light yellow clear liquid
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.518
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热
• 水溶解性: 水溶性：微溶；混溶：乙醇,甲醇

生物活性

• 描述: Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
• 相关类别:
  信号通路 >> 神经信号通路 >> 疼痛
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kurz A, Farlow M, Lefèvre G. Pharmacokinetics of a novel transdermal rivastigmine patch for the treatment of Alzheimer's disease: a review. Int J Clin Pract. 2009 May;63(5):799-805.

  [2]. Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther. 1998 Jul-Aug;20(4):634-47.

  [3]. Stryjer R, Ophir D, Bar F et al. Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia. Clin Neuropharmacol. 2012 Jul-Aug;35(4):161-4.

  [4]. Han HJ, Lee JJ, Park SA et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7(3):137-42.

安全

• 危害码 (欧洲): Xi

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