271576-80-8

• 常用中文名：3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑
• 常用英文名：SD-06
• CAS号：271576-80-8
• 分子式：C₂₀H₂₀ClN₅O₂
• 分子量：397.858
• 相关类别： 信号通路 MAPK/ERK信号通路 p38 MAPK
• 发布时间：2017-08-06 11:51:32
• 更新时间：2026-07-14 16:08:11
• SD 0006 (SD-06) 是p38 MAPK抑制剂,对 p38α 的 IC50 为170 nM,能抑制LPS诱导的TNF释放。

名称

• 中文名: 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑
• 英文名: 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone
• 中文别名: 3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑 1; 1-(4-(5-(4-氯苯基)-4-(嘧啶-4-基)-1H-吡唑-3-基)哌啶-1-基)-2-羟基乙酮; SD-06-1游离; SD-06,P38Α MAPK 的二芳基吡唑抑制剂
• 英文别名: 1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone; 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole; SD 0006, 10 mM in DMSO; SD 0006 ，S6502; Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy; SD 0006(SD-06); SD06; 2-{4-[5-(4-Chlorophenyl)-4-Pyrimidin-4-Yl-1h-Pyrazol-3-Yl]piperidin-1-Yl}-2-Oxoethanol; 1-{4-[5-(4-Chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl}-2-hydroxyethanone; 1-(4-(5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethan-1-one; 3hl7; SD-06-1; N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole; SD 0006; 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol; 1-{4-[5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl]piperidin-1-yl}-2-hydroxyethanone; SD-06;SD 06;SD06

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 652.6±55.0 °C at 760 mmHg
• 分子式: C₂₀H₂₀ClN₅O₂
• 分子量: 397.858
• 闪点: 348.5±31.5 °C
• 精确质量: 397.130554
• PSA: 95.00000
• LogP: 1.50
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.638
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: SD 0006 (SD-06) 是p38 MAPK抑制剂,对 p38α 的 IC50 为170 nM,能抑制LPS诱导的TNF释放。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
• 靶点:

  IC50: 170 nM (p38MAPK).

合成路线

271576-76-2 7397-62-8 ~80% 271576-80-8

文献：Allen, Kimberley C.; Anderson, Dennis K.; Baldus, John E.; Boehlow, Todd; Clark, Jerry D.; Dukesherer, Daniel R.; Edney, Albert D.; Fevig, Tom; Kundra, Sastry; Lawson, Jon P.; Lau, Patrick H.; McDermott, Lisa L.; Mao, Michael K.; Moe, Jodi L.; Mudipalli, Partha; Naing, Win; Selness, Shaun R.; Seymour, Christine B.; Schilke, Tobin C.; Viswanath, Shekhar; Walker, John K.; Yalamanchili, Gopichand Patent: US2003/225108 A1, 2003 ; Location in patent: Page 37-39 ;

271576-76-2 1113-60-6 ~% 271576-80-8

文献：Walker, John K.; Selness, Shaun R.; Devraj, Rajesh V.; Hepperle, Michael E.; Naing, Win; Shieh, Huey; Kurambail, Ravi; Yang, Syaulan; Flynn, Daniel L.; Benson, Alan G.; Messing, Dean M.; Dice, Tom; Kim, Tina; Lindmark; Monahan, Joseph B.; Portanova, Joseph Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2634 - 2638

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