271576-80-8
271576-80-8 structure
- Name: SD-06
- Chemical Name: 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone
- CAS Number: 271576-80-8
- Molecular Formula: C20H20ClN5O2
- Molecular Weight: 397.858
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2017-08-06 11:51:32
- Modify Date: 2024-01-14 15:48:50
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SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).
| Name | 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone |
|---|---|
| Synonyms |
SD06
2-{4-[5-(4-Chlorophenyl)-4-Pyrimidin-4-Yl-1h-Pyrazol-3-Yl]piperidin-1-Yl}-2-Oxoethanol 1-{4-[5-(4-Chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl}-2-hydroxyethanone SD-06 3hl7 N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy- 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol 1-{4-[5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl]piperidin-1-yl}-2-hydroxyethanone |
| Description | SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). |
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| Related Catalog | |
| Target |
IC50: 170 nM (p38MAPK). |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 652.6±55.0 °C at 760 mmHg |
| Molecular Formula | C20H20ClN5O2 |
| Molecular Weight | 397.858 |
| Flash Point | 348.5±31.5 °C |
| Exact Mass | 397.130554 |
| PSA | 95.00000 |
| LogP | 1.50 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.638 |
|
~80%
271576-80-8 |
| Literature: Allen, Kimberley C.; Anderson, Dennis K.; Baldus, John E.; Boehlow, Todd; Clark, Jerry D.; Dukesherer, Daniel R.; Edney, Albert D.; Fevig, Tom; Kundra, Sastry; Lawson, Jon P.; Lau, Patrick H.; McDermott, Lisa L.; Mao, Michael K.; Moe, Jodi L.; Mudipalli, Partha; Naing, Win; Selness, Shaun R.; Seymour, Christine B.; Schilke, Tobin C.; Viswanath, Shekhar; Walker, John K.; Yalamanchili, Gopichand Patent: US2003/225108 A1, 2003 ; Location in patent: Page 37-39 ; |
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~%
271576-80-8 |
| Literature: Walker, John K.; Selness, Shaun R.; Devraj, Rajesh V.; Hepperle, Michael E.; Naing, Win; Shieh, Huey; Kurambail, Ravi; Yang, Syaulan; Flynn, Daniel L.; Benson, Alan G.; Messing, Dean M.; Dice, Tom; Kim, Tina; Lindmark; Monahan, Joseph B.; Portanova, Joseph Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2634 - 2638 |
