SD-06
Modify Date: 2025-08-25 20:01:09
SD-06 structure
|
Common Name | SD-06 | ||
|---|---|---|---|---|
| CAS Number | 271576-80-8 | Molecular Weight | 397.858 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 652.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H20ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 348.5±31.5 °C | |
Use of SD-06SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). |
| Name | 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone |
|---|---|
| Synonym | More Synonyms |
| Description | SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po). |
|---|---|
| Related Catalog | |
| Target |
IC50: 170 nM (p38MAPK). |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 652.6±55.0 °C at 760 mmHg |
| Molecular Formula | C20H20ClN5O2 |
| Molecular Weight | 397.858 |
| Flash Point | 348.5±31.5 °C |
| Exact Mass | 397.130554 |
| PSA | 95.00000 |
| LogP | 1.50 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.638 |
|
~80%
SD-06 CAS#:271576-80-8 |
| Literature: Allen, Kimberley C.; Anderson, Dennis K.; Baldus, John E.; Boehlow, Todd; Clark, Jerry D.; Dukesherer, Daniel R.; Edney, Albert D.; Fevig, Tom; Kundra, Sastry; Lawson, Jon P.; Lau, Patrick H.; McDermott, Lisa L.; Mao, Michael K.; Moe, Jodi L.; Mudipalli, Partha; Naing, Win; Selness, Shaun R.; Seymour, Christine B.; Schilke, Tobin C.; Viswanath, Shekhar; Walker, John K.; Yalamanchili, Gopichand Patent: US2003/225108 A1, 2003 ; Location in patent: Page 37-39 ; |
|
~%
SD-06 CAS#:271576-80-8 |
| Literature: Walker, John K.; Selness, Shaun R.; Devraj, Rajesh V.; Hepperle, Michael E.; Naing, Win; Shieh, Huey; Kurambail, Ravi; Yang, Syaulan; Flynn, Daniel L.; Benson, Alan G.; Messing, Dean M.; Dice, Tom; Kim, Tina; Lindmark; Monahan, Joseph B.; Portanova, Joseph Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2634 - 2638 |
![4-[3-(4-chlorophenyl)-4-piperidin-4-yl-1H-pyrazol-5-yl]pyrimidine structure](https://image.chemsrc.com/caspic/497/271576-76-2.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| SD06 |
| 2-{4-[5-(4-Chlorophenyl)-4-Pyrimidin-4-Yl-1h-Pyrazol-3-Yl]piperidin-1-Yl}-2-Oxoethanol |
| 1-{4-[5-(4-Chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl}-2-hydroxyethanone |
| SD-06 |
| 3hl7 |
| N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole |
| Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy- |
| 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol |
| 1-{4-[5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl]piperidin-1-yl}-2-hydroxyethanone |