1037210-93-7

1037210-93-7结构式

中文名	Saridegib
英文名	N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide
中文别名	干扰素诱导T细胞趋化因子重组兔单抗
英文别名	Methanesulfonamide, N-[(2S,3R,3'R,3aS,4',6S,6',6'bS,7,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl] Sidegib (IPI-926 IP 9 unii-jt96fpu35x saridegib Sidegib Patidegib) Sidegib (Synonyms: IPI-926 ip9 free base N-[(3R,3'R,3'aS,4,6'S,6,6bS,7',9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide IPI-926 (SIDEGIB) IPI-926 ipi 926 FIN 5 fin-5 N-[(2S,3R,3'R,3aS,4',6S,6',6'bS,7,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-Eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]-methanesulfonamide N-[(3R,3'R,3'aS,4,6'S,6,6bS,7',9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide

描述	Saridegib 是 Smo 的特异性有效抑制剂,这是 Hedgehog 通路中关键的跨膜信号蛋白。
相关类别	信号通路 >> 干细胞及 Wnt 通路 >> SMO 研究领域 >> 癌症
靶点	Smo[1].
体内研究	来自基因工程的胰腺癌小鼠模型的证据表明,Saridegib(IPI-926)可以消耗肿瘤相关的基质组织并增加肿瘤内平均血管密度。这些变化导致同时施用的全身性药物如吉西他滨的递送增加,导致该小鼠模型中肿瘤负荷降低和存活延长[1]。
参考文献	[1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.