1037210-93-7
1037210-93-7 structure
- Name: Saridegib
- Chemical Name: N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide
- CAS Number: 1037210-93-7
- Molecular Formula: C29H48N2O3S
- Molecular Weight: 504.76800
- Catalog: Signaling Pathways Stem Cell/Wnt Smo
- Create Date: 2017-04-13 01:07:52
- Modify Date: 2026-07-17 11:22:52
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Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
| Name | N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide |
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| Synonyms |
Methanesulfonamide, N-[(2S,3R,3'R,3aS,4',6S,6',6'bS,7,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]
Sidegib (IPI-926 IP 9 unii-jt96fpu35x saridegib Sidegib Patidegib) Sidegib (Synonyms: IPI-926 ip9 free base N-[(3R,3'R,3'aS,4,6'S,6,6bS,7',9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide IPI-926 (SIDEGIB) IPI-926 ipi 926 FIN 5 fin-5 N-[(2S,3R,3'R,3aS,4',6S,6',6'bS,7,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-Eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]-methanesulfonamide N-[(3R,3'R,3'aS,4,6'S,6,6bS,7',9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide |
| Description | Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. |
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| Related Catalog | |
| Target |
Smo[1]. |
| In Vivo | Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents such as gemcitabine, leading to a decreased tumor burden and prolonged survival in this mouse model[1]. |
| References |
| Molecular Formula | C29H48N2O3S |
|---|---|
| Molecular Weight | 504.76800 |
| Exact Mass | 504.33900 |
| PSA | 75.81000 |
| LogP | 6.82930 |
| Storage condition | 2-8℃ |
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| Literature: WO2011/17551 A1, ; |
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| Literature: WO2011/17551 A1, ; |
| Precursor 4 | |
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| DownStream 0 | |