eucatropine

• 常用名: eucatropine
• 英文名: eucatropine
• CAS号: 100-91-4
• 分子量: 291.38500
• 密度: 1.11g/cm3
• 沸点: 388.7ºC at 760mmHg
• 分子式: C₁₇H₂₅NO₃
• 熔点: N/A
• 闪点: 188.8ºC

eucatropine用途

真阿托品是一种强效的毒蕈碱乙酰胆碱受体(mAChR)抑制剂,IC50值为0.583μM。真阿托品是一种抗胆碱能药物[1]。

eucatropine名称

• 英文名: (1,2,2,6-tetramethylpiperidin-4-yl) 2-hydroxy-2-phenylacetate

eucatropine生物活性

• 描述: 真阿托品是一种强效的毒蕈碱乙酰胆碱受体(mAChR)抑制剂,IC50值为0.583μM。真阿托品是一种抗胆碱能药物[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 体内研究: 真阿托品(0-200 mg/mL；ICV)作为 毫安时电阻拮抗剂,可通过猫的中枢胆碱能感受点产生行为效应[2]。
• 参考文献:

  [1]. Schmeller T, et, al. Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie. 1995 Jul;50(7):493-5.

  [2]. Beleslin DB, et, al. Comparative behavioral effects of anticholinergic agents in cats: psychomotor stimulation and aggression. Pharmacol Biochem Behav. 1986 Mar;24(3):581-6.

eucatropine物理化学性质

• 密度: 1.11g/cm3
• 沸点: 388.7ºC at 760mmHg
• 分子式: C₁₇H₂₅NO₃
• 分子量: 291.38500
• 闪点: 188.8ºC
• 精确质量: 291.18300
• PSA: 49.77000
• LogP: 2.46240
• InChIKey: QSAVEGSLJISCDF-UHFFFAOYSA-N
• SMILES: CC1CC(OC(=O)C(O)c2ccccc2)CC(C)(C)N1C
• 蒸汽压: 9.97E-08mmHg at 25°C

eucatropine靶点实验

查看更多实验

实验名称：Half life in mouse plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL4423497

实验名称：Half life in human plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL4423498

实验名称：Metabolic stability in human plasma assessed as parent compound remaining at 3 uM aft... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4384251

实验名称：Metabolic stability in CD-1 mouse plasma assessed as parent compound remaining at 3 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4384252

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Plasma stability in CD-1 mouse assessed as compound remaining measured after 2 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL5231947

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Plasma stability in human assessed as compound remaining measured after 2 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL5231946

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Vibrio cholerae assay for pro-quorum sensing small molecules 来源：Southern Research Specialized Biocontainment Screening Center 靶标：cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] External Id：Vcholera_QS_Pilot

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eucatropine英文别名

• Eucatropina
• eucatropine
• n-methyl-b-vinyldiacetonaikamine mandelate
• Eucatropinum