扎达维林

• 常用名: 扎达维林
• 英文名: Zardaverine
• CAS号: 101975-10-4
• 分子量: 268.216
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₂H₁₀F₂N₂O₃
• 熔点: N/A
• 闪点: N/A

扎达维林用途

Zardaverine是新型的PDE3和4抑制剂,IC50分别为0.5 uM和0.8 uM。

扎达维林名称

• 中文名: 扎达维林
• 英文名: zardaverine
• 中文别名: 6-[4-(二氟甲氧基)-3-甲氧基苯基]-3(2H)-吡哒嗪酮

扎达维林生物活性

• 描述: Zardaverine是新型的PDE3和4抑制剂,IC50分别为0.5 uM和0.8 uM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. R.T. Schermuly, H. Leuchte, H.A. Ghofrani, et al. Zardaverine and aerosolised iloprost in a model of acute respiratoryfailure. ERJ, 2003 ,22 (2): 342-347.

  [2]. D. Ukena, K. Rentz, C. Reiber, et al. Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Respiratory Medicine.1995, 89 ( 6) : 441-444.

  [3]. Schade FU, Schudt C. The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages. European Journal of Pharmacology.1993, 230(1):9-14.

扎达维林物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₂H₁₀F₂N₂O₃
• 分子量: 268.216
• 精确质量: 268.065948
• PSA: 64.21000
• LogP: 0.90
• InChIKey: HJMQDJPMQIHLPB-UHFFFAOYSA-N
• SMILES: COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F
• 折射率: 1.555
• 储存条件: 2-8℃
• 计算化学:

  1.疏水参数计算参考值（XlogP）:2.2

  2.氢键供体数量:1

  3.氢键受体数量:6

  4.可旋转化学键数量:4

  5.互变异构体数量:2

  6.拓扑分子极性表面积:59.9

  7.重原子数量:19

  8.表面电荷:0

  9.复杂度:398

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

扎达维林MSDS

扎达维林MSDS英文版

扎达维林安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

扎达维林靶点实验

查看更多实验

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Inhibitory concentration against phosphodiesterase 1 from bovine, calmodulin 来源：ChEMBL 靶标：Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B External Id：CHEMBL764106

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

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扎达维林英文别名

• 3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one
• Zardaverine
• 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
• zardaverinum
• zardaverina
• 6-[4-(Difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one