A-940894

• 常用名: A-940894
• 英文名: A-940894
• CAS号: 1027330-82-0
• 分子量: 295.38200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₁N₅
• 熔点: N/A
• 闪点: N/A

A-940894用途

A-940894 是有效的组胺H4 受体的拮抗剂,其Ki 值分别为7.6 nM (大鼠 H4) 和71 nM (人H4).

A-940894名称

• 英文名: 4-piperazin-1-yl-6,7-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyrimidin-2-amine

A-940894生物活性

• 描述: A-940894 是有效的组胺H4 受体的拮抗剂,其Ki 值分别为7.6 nM (大鼠 H4) 和71 nM (人H4).
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点实验:

  Ki: 7.6 nM (rat H4), 71 nM (human H4)[1].

• 参考文献:

  [1]. M I Strakhova, et al. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br J Pharmacol. 2009 May;157(1):44-54.

A-940894物理化学性质

• 分子式: C₁₇H₂₁N₅
• 分子量: 295.38200
• 精确质量: 295.18000
• PSA: 67.80000
• LogP: 1.94800
• InChIKey: KUZRWWLVBUPCRK-UHFFFAOYSA-N
• SMILES: Nc1nc2c(c(N3CCNCC3)n1)CCCc1ccccc1-2

A-940894靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for histamine H1 recept... 来源：ChEMBL 靶标：N/A External Id：CHEMBL986310

实验名称：Radioligand Binding Assay from Article 10.1021/jm800670r: "Rotationally constrained 2... 来源：BindingDB 靶标：N/A External Id：BindingDB_2964_1

实验名称：Blockade of histamine-induced morphological changes in BALB/c mouse BMMC by flow cyto... 来源：ChEMBL 靶标：N/A External Id：CHEMBL986309

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for human histamine H3 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL989042

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for histamine H2 recept... 来源：ChEMBL 靶标：N/A External Id：CHEMBL989041

实验名称：Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 ce... 来源：ChEMBL 靶标：Histamine H4 receptor External Id：CHEMBL986307

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for adrenergic alpha1 r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL989047

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for 5HT1D receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL989044

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for 5HT1A receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL989043

实验名称：Selectivity ratio of Ki for human histamine H4 receptor to Ki for dopamine D2 recepto... 来源：ChEMBL 靶标：N/A External Id：CHEMBL989046

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A-940894英文别名

• 2,4-diamino-5,6-disubstituted pyrimidine,9
• UNII-8U5620H545