(R)-普拉克索

• 常用名: (R)-普拉克索
• 英文名: Dexpramipexole
• CAS号: 104632-28-2
• 分子量: 211.331
• 密度: 1.17±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₇N₃S
• 熔点: 270-272ºC
• 闪点: N/A

(R)-普拉克索用途

Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole,是神经保护剂,是弱的非麦角类多巴胺受体激动剂。

(R)-普拉克索名称

• 中文名: R-普拉克索
• 英文名: (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
• 中文别名: (R)-普拉克索二盐酸化物 | (R)-普拉克索 | 普拉克索杂质E

(R)-普拉克索生物活性

• 描述: Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole,是神经保护剂,是弱的非麦角类多巴胺受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler

  [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.

  [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.

  [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

  [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.

(R)-普拉克索物理化学性质

• 密度: 1.17±0.1 g/cm3
• 熔点: 270-272ºC
• 分子式: C₁₀H₁₇N₃S
• 分子量: 211.331
• PSA: 83.52000
• LogP: 4.38490
• InChIKey: FASDKYOPVNHBLU-SSDOTTSWSA-N
• SMILES: CCCNC1CCc2nc(N)sc2C1
• 储存条件: 室温，干燥，密封
• 水溶解性: Slightly soluble (1.1 g/L) (25 ºC)

(R)-普拉克索安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

(R)-普拉克索海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(R)-普拉克索靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for displacement of displacement of [3H]N-methylspiperone fro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4815487

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Agonist activity at human histamine H2 receptor expressed in HEK293T cells co-express... 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL4815481

实验名称：Agonist activity at human histamine H2 receptor expressed in HEK293T cells co-express... 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL4815482

实验名称：Agonist activity at human histamine receptor expressed in sf9 insect cell membranes c... 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL4815479

实验名称：Agonist activity at human histamine H2 receptor expressed in sf9 insect cell membrane... 来源：ChEMBL 靶标：Histamine H2 receptor External Id：CHEMBL4815480

实验名称：Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293T cel... 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL4815485

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Selectivity ratio of Ki for displacement of displacement of [3H]N-methylspiperone fro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4815486

实验名称：Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293T ce... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL4815484

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(R)-普拉克索英文别名

• Dexpramipexole
• (6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
• (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
• (6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine
• (R)-Pramipexole Dihydrochloride
• Pramipexole [USAN:INN]
• (R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole
• (R)-Pramipexole
• (R)-(+)-pramipexole