BI-671800

• 常用名: BI-671800
• 英文名: BI-671800
• CAS号: 1093108-50-9
• 分子量: 501.50100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₆F₃N₅O₃
• 熔点: N/A
• 闪点: N/A

BI-671800用途

BI-671800 是高特异性的、有效的前列腺素 D2 受体 (DP2/CRTH2) 的拮抗剂,其对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50 值分别为 4.5 nM 和 3.7 nM[1]。有治疗哮喘的潜能[2]。

BI-671800名称

• 中文名: BI-671800
• 英文名: 2-[4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]pyrimidin-5-yl]acetic acid

BI-671800生物活性

• 描述: BI-671800 是高特异性的、有效的前列腺素 D2 受体 (DP2/CRTH2) 的拮抗剂,其对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50 值分别为 4.5 nM 和 3.7 nM[1]。有治疗哮喘的潜能[2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  hCRTH2:4.5 nM (IC50, in CRTH2 transfected cells)

  mCRTH2:3.7 nM (IC50, in CRTH2 transfected cells)

• 体外研究: BI-671800(化合物A)在转染细胞中作为人或小鼠CRTH2的拮抗剂表现出低nM效力[1]。
• 体内研究: BI-671800(化合物A,0.1-10mg/kg,ig)显示出对小鼠的AHR的显着抑制[1]。 BI-671800(化合物A)有效阻断水肿形成,并大大减少药物载体治疗动物中观察到的炎症浸润和皮肤病理[3]。
• 参考文献:

  [1]. Boehme SA, et al. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol. 2009 Jan;21(1):81-93.

  [2]. Miller D, et al. A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma. Allergy Asthma Proc. 2017 Mar 1;38(2):157-164.

  [3]. Lukacs NW, et al. CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L767-79.

BI-671800物理化学性质

• 分子式: C₂₅H₂₆F₃N₅O₃
• 分子量: 501.50100
• 精确质量: 501.19900
• PSA: 102.15000
• LogP: 4.48160
• InChIKey: XEOSTBFUCNZKGS-UHFFFAOYSA-N
• SMILES: CN(C)c1nc(Cc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)nc(N(C)C)c1CC(=O)O
• 储存条件: 2-8℃

BI-671800靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

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BI-671800英文别名

• UNII-721F767LHB
• Actimis
• BI-671800