(D-ARG0,HYP3,D-PHE7)-BRADYKININ

• 常用名: (D-ARG0,HYP3,D-PHE7)-BRADYKININ
• 英文名: (D-Arg0,Hyp3,D-Phe7)-Bradykinin trifluoroacetate salt
• CAS号: 109333-26-8
• 分子量: 1282.45
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₆₀H₈₇N₁₉O₁₃
• 熔点: N/A
• 闪点: N/A

(D-ARG0,HYP3,D-PHE7)-BRADYKININ用途

NPC-567是缓激肽B2受体拮抗剂。NPC-567在抑制气道中对过敏原的急性反应方面是有效的[1][2]。

(D-ARG0,HYP3,D-PHE7)-BRADYKININ名称

• 中文名: (D-ARG0,HYP3,D-PHE7)-BRADYKININ
• 英文名: [D-Arg0,Hyp3,D-Phe7]-Bradykinin

(D-ARG0,HYP3,D-PHE7)-BRADYKININ生物活性

• 描述: NPC-567是缓激肽B2受体拮抗剂。NPC-567在抑制气道中对过敏原的急性反应方面是有效的[1][2]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 缓激肽受体
• 参考文献:

  [1]. Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72.

  [2]. Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9.

(D-ARG0,HYP3,D-PHE7)-BRADYKININ物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₆₀H₈₇N₁₉O₁₃
• 分子量: 1282.45
• 精确质量: 1281.673096
• PSA: 533.80000
• LogP: -2.56
• InChIKey: RBIXVHPHNGXTCI-QJTYZATASA-N
• SMILES: NC(N)=NCCCC(N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)O
• 折射率: 1.691

(D-ARG0,HYP3,D-PHE7)-BRADYKININ安全信息

• WGK德国: 3

(D-ARG0,HYP3,D-PHE7)-BRADYKININ靶点实验

查看更多实验

实验名称：Binding affinity for bradykinin receptor of SV-T2 fibroblasts 来源：ChEMBL 靶标：SV-T2 External Id：CHEMBL657647

实验名称：Binding affinity of compound was measured for bradykinin receptor in guinea pig ileum 来源：ChEMBL 靶标：N/A External Id：CHEMBL657651

实验名称：Antagonistic activity of compound was measured for bradykinin receptor in guinea pig ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL657652

实验名称：Antagonistic activity of compound was measured in SV-T2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL807393

实验名称：Mouse B2 receptor (Bradykinin receptors) 来源：IUPHAR-DB 靶标：B2 receptor (Bradykinin receptors) [Mus musculus] External Id：42_Mouse

实验名称：Human B2 receptor (Bradykinin receptors) 来源：IUPHAR-DB 靶标：B2 receptor (Bradykinin receptors) [Homo sapiens] External Id：42_Human

实验名称：Displacement of [3H]bradykinin from bradykinin receptor in guinea pig ileal membrane 来源：ChEMBL 靶标：N/A External Id：CHEMBL657645

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(D-ARG0,HYP3,D-PHE7)-BRADYKININ英文别名

• (D-ARG0,HYP3,D-PHE7)-BRADYKININ
• D-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-D-Arg-OH
• D-ARG-ARG-PRO-HYDROXY-PRO-GLY-PHE-SER-D-PHE-PHE-ARG
• D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG
• D-Phe7]-bradykinin
• D-Arg-Arg-Pro-Hyp-Gly-Phe-Phe-Arg
• (D-Arg0,Hyp3,D-Phe7)bradikinin
• D-Arg[Hyp3,D-Phe7]-bradykinin
• D-Arg-Arg-Pro-t4Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH
• npc567
• D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-L-Arg-OH
• D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-L-arginine
• H-D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG-OH