(1S,2S)-硼替佐米

• 常用名: (1S,2S)-硼替佐米
• 英文名: (1S,2S)-Bortezomib
• CAS号: 1132709-14-8
• 分子量: 384.237
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₉H₂₅BN₄O₄
• 熔点: N/A
• 闪点: N/A

(1S,2S)-硼替佐米用途

(1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物,也是第一种用于人类的蛋白酶体抑制剂。

(1S,2S)-硼替佐米名称

• 中文名: 硼替佐米杂质E
• 英文名: [(1S)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

(1S,2S)-硼替佐米生物活性

• 描述: (1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物,也是第一种用于人类的蛋白酶体抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
• 靶点实验:

  Ki: 0.6 nM (20S proteasome)[1]

• 参考文献:

  [1]. Kamalzadeh Z, et al. Determination of Bortezomib in API Samples Using HPLC: Assessment of Enantiomeric and Diastereomeric Impurities. J Chromatogr Sci. 2017 Aug 1;55(7):697-705.

  [2]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22.

  [3]. Shahshahan MA, et al. Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects. Am J Cancer Res. 2011;1(7):913-24.

(1S,2S)-硼替佐米物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₁₉H₂₅BN₄O₄
• 分子量: 384.237
• 精确质量: 384.196899
• PSA: 131.42000
• LogP: 2.45
• InChIKey: GXJABQQUPOEUTA-DOTOQJQBSA-N
• SMILES: CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
• 折射率: 1.564
• 储存条件: 2-8°C，干燥，密封

(1S,2S)-硼替佐米安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

(1S,2S)-硼替佐米海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(1S,2S)-硼替佐米靶点实验

查看更多实验

实验名称：Inhibition of gamma-secretase-mediated betaAPP K670N/M671L mutant cleavage in HEK293 ... 来源：ChEMBL 靶标：Gamma-secretase subunit APH-1B External Id：CHEMBL2344497

实验名称：Inhibition of presenilin-dependent gamma secretase complex in HEK293 solubilized memb... 来源：ChEMBL 靶标：Gamma-secretase subunit APH-1B External Id：CHEMBL2346355

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：S16 Schwann cell PMP22 intronic element firefly luciferase assay 来源：NCGC 靶标：peripheral myelin protein 22 [Rattus norvegicus] External Id：cmt-p4-fluc-fda_regid

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in H... 来源：Southern Research Institute 靶标：CFTR External Id：CF Folding

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

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(1S,2S)-硼替佐米英文别名

• [(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid
• N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
• N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide
• HMS2089J16
• (1S,2S)-Bortezomib
• ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid