Neuropeptide γ trifluoroacetate salt

• 常用名: Neuropeptide γ trifluoroacetate salt
• 英文名: Neuropeptide γ trifluoroacetate salt
• CAS号: 114882-65-4
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: C₉₉H₁₅₈N₃₄O₂₉S
• 熔点: N/A
• 闪点: N/A

用途

γ-神经肽(兔)可从兔肠中分离得到。γ-神经肽是一种内源性神经激肽,作为神经激肽2(NK2)受体激动剂。γ-神经肽介导下丘脑-垂体-肾上腺(HPA)轴,以及生殖激素释放[1][2][3]。

名称

• 英文名: (3S)-3-amino-4-[[(1S)-2-[[2-[[(1S)-2-[[2-[[(1S)-4-amino-1-[[(1S,2S)-1-[[(1S)-2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-2-[[(1S)-5-amino-1-[[(1S,2R)-1-[[(1S)-2-[[(1S)-2-[[(1S)-1-benzyl-2-[[(1S)-1-[[2-[[(1S)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(carboxymethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pentyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-4-oxo-butyl]amino]-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoic acid

生物活性

• 描述: γ-神经肽(兔)可从兔肠中分离得到。γ-神经肽是一种内源性神经激肽,作为神经激肽2(NK2)受体激动剂。γ-神经肽介导下丘脑-垂体-肾上腺(HPA)轴,以及生殖激素释放[1][2][3]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
• 靶点实验:

  NK2

• 体外研究: γ-神经肽诱导完整雄性大鼠半垂体释放 左手到培养基中[3]。 γ-神经肽(1 nM-100 nM)对雄性大鼠垂体前叶的 高释放没有影响[4]。
• 体内研究: γ-神经肽(兔)(0.4-2.0nmol/kg静脉注射) 可降低兔的血压[2]。 γ-神经肽(0.5-10 nmol,i.c.v)刺激雄性大鼠中血浆 左手的增加[4]。
• 参考文献:

  [1]. Kage R, et al. Neuropeptide-gamma: a peptide isolated from rabbit intestine that is derived from gamma-preprotachykinin. J Neurochem. 1988 May;50(5):1412-7.

  [2]. Yuan L, et al. Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit. Pulm Pharmacol Ther. 1998 Feb;11(1):31-9.

  [3]. Debeljuk L, et al. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides. 1999;20(2):285-99.

  [4]. Kalra PS, et al. Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action. Endocrinology. 1992 Sep;131(3):1195-201.

  [5]. Debeljuk L, et al. In vivo and in vitro effects of neuropeptide K and neuropeptide gamma on the release of growth hormone. Neuroreport. 1995 Dec 15;6(18):2457-60.

物理化学性质

• 分子式: C₉₉H₁₅₈N₃₄O₂₉S
• InChIKey: NISSWFHUIGHJLY-DKRDOARVSA-N
• SMILES: CCC(C)C(NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(C)NC(=O)C(N)CC(=O)O)C(=O)NC(CO)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O)C(C)C)C(C)O