曲贝替定

• 常用名: 曲贝替定
• 英文名: Trabectedin
• CAS号: 114899-77-3
• 分子量: 761.837
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₉H₄₃N₃O₁₁S
• 熔点: N/A
• 闪点: N/A

曲贝替定用途

Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。

曲贝替定名称

• 中文名: 他比特啶
• 英文名: trabectedin
• 中文别名: 他比特定 | 曲贝替定

曲贝替定生物活性

• 描述: Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.

  [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.

  [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.

  [4]. Sessa C, et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer. 2009 Aug;45(12):2116-22.

曲贝替定物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₃₉H₄₃N₃O₁₁S
• 分子量: 761.837
• 精确质量: 761.261841
• PSA: 194.02000
• LogP: 3.10
• InChIKey: PKVRCIRHQMSYJX-XHKCZRNKSA-N
• SMILES: COc1cc2c(cc1O)CCNC21CSC2c3c(OC(C)=O)c(C)c4c(c3C(COC1=O)N1C(O)C3Cc5cc(C)c(OC)c(O)c5C(C21)N3C)OCO4
• 折射率: 1.732
• 储存条件: -20°C

曲贝替定靶点实验

查看更多实验

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Inhibition of MDR1 in human KB-C2 cells assessed as potentiation of vincristine-induc... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4191979

实验名称：qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr... 来源：824 靶标：N/A External Id：SPEC167MG

实验名称：qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free... 来源：824 靶标：N/A External Id：SPEC167MR

实验名称：In vivo antitumor activity against mouse P388 cells at 15 ug/kg relative to control 来源：ChEMBL 靶标：P388 External Id：CHEMBL1018066

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells 来源：824 靶标：N/A External Id：SPEC167CG

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell fre... 来源：824 靶标：N/A External Id：SPEC167MB

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曲贝替定英文别名

• ecteinascidin-743
• (1R,1'R,2'R,3'R,11'S,12'S,14'R)-5',6,12'-Trihydroxy-6',7-dimethoxy-7',21',30'-trimethyl-27'-oxo-3,4-dihydro-2H-spiro[isoquinoline-1,26'-[17,19,28]trioxa[24]thia[13,30]diazaheptacyclo[12.9.6.1.0.0.0.0]triaconta[4,6,8,15,20,22]hexaen]-22'-yl acetate
• ET-743
• Trabectedin
• ecteinascidin 743
• (1'R,6R,6aR,7R,13S,14S,16R)
• Ecteinascidine 743
• Ecteinascidin
• ET743
• Yondelis(R)
• UNII-ID0YZQ2TCP
• 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,[6R-(6a,6a3,73,133,143,16a,20R*)]
• Yondelis