114899-77-3

• 常用中文名：曲贝替定
• 常用英文名：Trabectedin
• CAS号：114899-77-3
• 分子式：C₃₉H₄₃N₃O₁₁S
• 分子量：761.837
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2018-04-16 08:00:00
• 更新时间：2026-07-01 19:51:16
• Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。

名称

• 中文名: 他比特啶
• 英文名: trabectedin
• 中文别名: 曲贝替定(GMP); 曲贝替定/曲贝替丁; 他比特定; 曲贝替定/他比特定; 曲贝替丁; 曲贝替定,10 MM DMSO 溶液; 他比特啶; (1′R,6R,6,7R,13S,14S,16R)-5-(乙酰氧基)-3′,4′,6,6A,7,13,14,16-八氢-6′,8,14-三羟基-7′,9-二甲氧基-4,10,23-三甲基螺[6,16-(环硫基丙氧基甲桥)-7,13-亚氨基-12H-1,3-二氧杂环戊并[7,8]异喹啉并[3,2-B]苯并氮杂辛环-20,1′(2′H)-异喹啉]-19-酮; 曲贝替定/他比特啶; Trabectedin试剂; TRABECTEDIN曲贝替定
• 英文别名: ecteinascidin-743; Trabectedin(Ecteinascidin 743,NSC-684766,ET-743, Yondelis); (1'R,6R,6,7R,13S,14S,16R); (1R,1'R,2'R,3'R,11'S,12'S,14'R)-5',6,12'-Trihydroxy-6',7-dimethoxy-7',21',30'-trimethyl-27'-oxo-3,4-dihydro-2H-spiro[isoquinoline-1,26'-[17,19,28]trioxa[24]thia[13,30]diazaheptacyclo[12.9.6.1.0.0.0.0]triaconta[4,6,8,15,20,22]hexaen]-22'-yl acetate; TrabectedinQ: What is Trabectedin Q: What is the CAS Number of Trabectedin Q: What is the storage condition of Trabectedin Q: What e the applications of Trabectedin; Qubetidine; ecteinascidin; ecteinascidin 743; Trabectedin Ecteinascidin; ecteinascidin 743,Trabectedin,ET; Trabectedin (Yondelis); (1'R,6R,6aR,7R,13S,14S,16R); Ecteinascidine 743; Ecteinascidin; Trabectedin, 10 mM in DMSO; ET743; Trabectedin-d3/Ecteinascidin 743-d3/ET-743-d3; ASMF Filed; Yondelis R ,Trabectedin; 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,[6R-(6a,6a3,73,133,143,16a,20R*)]; NSC-684766; cteinascidin; ET 743,Ecteinascidin743,inhibit,ROS,Inhibitor,Trabectedin,backbone,Ecteinascidin-743,Cytotoxicity,tetrahydroisoquinoline,superoxides,ET743,DNA,Apoptosis,alkaloid,cell-cycle,anti-inflammatory,antitumor,Reactive Oxygen Species; (1′R,6R,6,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-ithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b]benzazocine-20,1′(2′H)-isoquinolin]-19-one; ET-743; Ecteinascidine; Trabectedin(Ecteinascidin 743,NSC-684766,ET-743); Yondelis(R); Spiro[6,16-ithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b]benzazocine-20,1'(2'H)-isoquinolin]-19-one, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6,7R,13S,14S,16R); UNII-ID0YZQ2TCP; ECTEINASCIDIN 743; ET-743; ECTEINASCIDIN; Yondelis

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₃₉H₄₃N₃O₁₁S
• 分子量: 761.837
• 精确质量: 761.261841
• PSA: 194.02000
• LogP: 3.10
• 折射率: 1.732
• 储存条件: -20°C

生物活性

• 描述: Trabectedin (Ecteinascidin-743 or ET-743)是海洋来源的抗癌剂。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.

  [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.

  [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.

  [4]. Sessa C, et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer. 2009 Aug;45(12):2116-22.

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