NSC102533

• 常用名: NSC102533
• 英文名: 4-hydroxy-3-phenyl-naphthalene-1,2-dione
• CAS号: 1150-59-0
• 分子量: 250.24900
• 密度: 1.392g/cm3
• 沸点: 445.3ºC at 760 mmHg
• 分子式: C₁₆H₁₀O₃
• 熔点: N/A
• 闪点: 237.2ºC

NSC102533用途

抗疟剂14(化合物N3)是线粒体电子转运的有效抑制剂。抗疟剂14可以用作抗疟药[1]。

NSC102533名称

• 中文名: NSC102533
• 英文名: 2-hydroxy-3-phenylnaphthalene-1,4-dione

NSC102533生物活性

• 描述: 抗疟剂14(化合物N3)是线粒体电子转运的有效抑制剂。抗疟剂14可以用作抗疟药[1]。
• 相关类别:
  研究领域 >> 感染
• 靶点实验:

  mitochondrial electron transport[1]

• 体外研究: 抗疟剂14(化合物N3)(0-400μM,48小时)抑制恶性疟原虫,对人类细胞的细胞毒性有限[1]。抗疟剂14抑制恶性疟原虫线粒体膜电位,IC50Δ。细胞毒性试验[1]细胞系：恶性疟原虫和HEK293T浓度：0.128、0.64、3.2、16、80和400μM孵育时间：48小时结果：显示对恶性疟原菌的IC50为443 nM,显示细胞毒性,CC50为54.6±0.23μM。
• 参考文献:

  [1]. Schuck DC, et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10;12:234.

NSC102533物理化学性质

• 密度: 1.392g/cm3
• 沸点: 445.3ºC at 760 mmHg
• 分子式: C₁₆H₁₀O₃
• 分子量: 250.24900
• 闪点: 237.2ºC
• 精确质量: 250.06300
• PSA: 54.37000
• LogP: 3.03490
• InChIKey: HCKUADBGJIXWTR-UHFFFAOYSA-N
• SMILES: O=C1C(=O)c2ccccc2C(O)=C1c1ccccc1
• 外观性状: 黄色固体
• 蒸汽压: 1.04E-08mmHg at 25°C
• 折射率: 1.693
• 储存条件: -20℃

NSC102533靶点实验

查看更多实验

实验名称：Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed a... 来源：ChEMBL 靶标：P2X purinoceptor 7 External Id：CHEMBL4252246

实验名称：Cytotoxicity against Swiss Webster mouse peritoneal macrophages at 100 uM after 72 hr... 来源：ChEMBL 靶标：Peritoneal macrophage External Id：CHEMBL4252245

实验名称：Selectivity index, ratio of CC50 for Swiss Webster mouse peritoneal macrophages to IC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4252248

实验名称：Intrinsic clearance in mouse liver microsomes assessed per mg of protein at 1 uM prei... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4252254

实验名称：In vitro concentration required to reduce the proportion of schizont infected cells i... 来源：ChEMBL 靶标：Theileria parva External Id：CHEMBL811437

实验名称：Safety index, ratio of test compound CC50 to A740003 CC50 for Swiss Webster mouse per... 来源：ChEMBL 靶标：Peritoneal macrophage External Id：CHEMBL4252253

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells at 100 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4252256

实验名称：Intrinsic clearance in human liver microsomes assessed per mg of protein at 1 uM prei... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4252255

实验名称：Safety index, ratio of test compound CC50 to BGG CC50 for Swiss Webster mouse periton... 来源：ChEMBL 靶标：Peritoneal macrophage External Id：CHEMBL4252252

实验名称：Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed a... 来源：ChEMBL 靶标：P2X purinoceptor 7 External Id：CHEMBL4252262

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NSC102533英文别名

• 2-methyl-2-propenoicaci2-hydroxy-3-phenoxypropylester
• Methacrylic acid 2-hydroxy-3-phenoxypropyl ester
• 2-hydroxynaphthoquinone
• 2-Hydroxy-3-phenoxypropyl-methacrylat
• 3-PHENOXY-2-HYDROXYPROPYL METHACRYLATE
• 2-hydroxy-3-phenyl-1,4-naphthalenedione
• 2-Hydroxy-3-phenyl-[1,4]naphthochinon
• 3-Phenoxy-2-hydroxypropyl methacryla
• 2-Propenoicacid,2-methyl-,2-hydroxy-3-phenoxypropylester
• 3-hydroxy-2-phenyl-1,4-naphthoquinone
• 2-hydroxy-3-phenyl-1,4-naphthoquinone
• 3-O-Phenylglycerol 1-methacrylate