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arg-pro-pro-gly-phe-ser-pro-leu acetate salt

更新时间:2025-09-07 17:50:45

arg-pro-pro-gly-phe-ser-pro-leu acetate salt结构式
arg-pro-pro-gly-phe-ser-pro-leu acetate salt结构式
品牌特惠专场
常用名 arg-pro-pro-gly-phe-ser-pro-leu acetate salt 英文名 arg-pro-pro-gly-phe-ser-pro-leu acetate salt
CAS号 115035-45-5 分子量 930.06
密度 N/A 沸点 N/A
分子式 C43H67N11O12 熔点 N/A
MSDS 美版 闪点 N/A

 用途


Des-Arg9-[Leu8]-Bradykinin acetate 是有效的 缓激肽受体1 (B1R) 拮抗剂。Des-Arg9-[Leu8]-Bradykinin acetate 可用于肾纤维化研究。

 名称

英文名 arg-pro-pro-gly-phe-ser-pro-leu acetate salt
英文别名 更多

 生物活性

描述 Des-Arg9-[Leu8]-Bradykinin acetate 是有效的 缓激肽受体1 (B1R) 拮抗剂。Des-Arg9-[Leu8]-Bradykinin acetate 可用于肾纤维化研究。
相关类别
靶点实验

IC50: B1R[1]

参考文献

[1]. Ji-Zhe Jin, et al. Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction. Acta Pharmacol Sin. 2020 Dec;41(12):1597-1608.  

 物理化学性质

分子式 C43H67N11O12
分子量 930.06
精确质量 929.49700
PSA 360.08000
LogP 0.84570
InChIKey XBFMNOKHQZCARQ-XXZMQFNDSA-N
SMILES CC(=O)O.CC(C)CC(NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(=O)O

 安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3

 文献3

更多文献
Upregulation of B1 receptor mediating des-Arg9-BK-induced rat paw oedema by systemic treatment with bacterial endotoxin.

Br. J. Pharmacol. 117 , 793-798, (1996)

1. The effect of pretreatment with bacterial endotoxin (LPS, 10 micrograms, i.v., 24 h) on the bradykinin B1 and B2 receptor-induced oedema in the rat paw, and the interaction of B1-mediated responses...

Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade.

Hypertension 48 , 942-949, (2006)

It has been suggested that the effects of angiotensin II type 1 receptor (AT1R) blockers are in part because of angiotensin II type 2 receptor (AT2R) signaling. Interactions between the AT2R and kinin...

The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice.

Neuropharmacology 54 , 597-604, (2008)

The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC). In the present study, we examine the contribut...

 英文别名

arg-pro-pro-gly-phe-ser-pro-leu acoh 3h2o
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