砂生槐异黄酮 A

• 常用名: 砂生槐异黄酮 A
• 英文名: Sophora-iso-flavone A
• CAS号: 117204-81-6
• 分子量: 352.34
• 密度: 1.4±0.1 g/cm3
• 沸点: 611.2±55.0 °C at 760 mmHg
• 分子式: C₂₀H₁₆O₆
• 熔点: 235-237℃
• 闪点: 223.9±25.0 °C

砂生槐异黄酮 A用途

Sophoraisoflavone A(Allolicoisoflavone B)是从甘草中分离得到的一种天然产物。Sophoraiseflane A是一种有效的蛋白酪氨酸磷酸酶1B(PTP1B)抑制剂,其IC50值为0.80μM。Sophoraisoflavone A可用于炎症研究[1]。

砂生槐异黄酮 A名称

• 中文名: 砂生槐异黄酮 A
• 英文名: 5,5',7-trihydroxy-2',2'-dimethyl-2'H,4H-[3,8'-bichromen]-4-one

砂生槐异黄酮 A生物活性

• 描述: Sophoraisoflavone A(Allolicoisoflavone B)是从甘草中分离得到的一种天然产物。Sophoraiseflane A是一种有效的蛋白酪氨酸磷酸酶1B(PTP1B)抑制剂,其IC50值为0.80μM。Sophoraisoflavone A可用于炎症研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Lin Y, et, al. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorg Med Chem. 2017 Jul 15;25(14):3706-3713.

砂生槐异黄酮 A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 611.2±55.0 °C at 760 mmHg
• 熔点: 235-237℃
• 分子式: C₂₀H₁₆O₆
• 分子量: 352.34
• 闪点: 223.9±25.0 °C
• 精确质量: 352.094696
• PSA: 100.13000
• LogP: 5.33
• InChIKey: RIDRQWKYWXHAOD-UHFFFAOYSA-N
• SMILES: CC1(C)C=Cc2c(O)ccc(-c3coc4cc(O)cc(O)c4c3=O)c2O1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.683
• 储存条件: -20°C，密封，干燥

砂生槐异黄酮 A靶点实验

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实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 1... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4035961

实验名称：Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4035959

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4035957

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4035954

实验名称：Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4035952

实验名称：Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4035953

实验名称：Growth inhibition of human LO2 cells at 10 uM after 24 hrs by MTS assay relative to c... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4035948

实验名称：Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated fo... 来源：ChEMBL 靶标：Polyphenol oxidase 4 External Id：CHEMBL4035963

实验名称：Growth inhibition of human HEK293T cells at 10 uM after 24 hrs by MTS assay relative ... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL4035947

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砂生槐异黄酮 A英文别名

• Sophora-iso-flavone A
• 5,5',7-Trihydroxy-2',2'-dimethyl-2'H,4H-3,8'-bichromen-4-one