BRL-15572 hydrochloride

• 常用名: BRL-15572 hydrochloride
• 英文名: BRL 15572 hydrochloride
• CAS号: 1173022-77-9
• 分子量: 443.409
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₈Cl₂N₂O
• 熔点: N/A
• 闪点: N/A

BRL-15572 hydrochloride用途

BRL-15572 hydrochloride 是 h5-HT1D 的选择性拮抗剂,对 h5-HT1D 受体显示出高亲和力。 BRL-15572 hydrochloride 可能是表征 h5-HT1D 受体介导的反应的有用药理剂。

BRL-15572 hydrochloride名称

• 中文名: BRL 15572 盐酸盐
• 英文名: TCMDC-123456

BRL-15572 hydrochloride生物活性

• 描述: BRL-15572 hydrochloride 是 h5-HT1D 的选择性拮抗剂,对 h5-HT1D 受体显示出高亲和力。 BRL-15572 hydrochloride 可能是表征 h5-HT1D 受体介导的反应的有用药理剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT1D Receptor

• 体外研究: BRL-15572对h5-HT1D(pKi=7.9)的亲和力比CHO细胞中表达的5-HT1B受体高60倍[1]。BRL-15572(0.1nm-10μM)刺激表达h5-HT1B和h5-HT1D受体的CHO细胞膜[35S]GTPγS结合[1]。
• 体内研究: BRL-15572在福尔马林试验中预防(-)-表儿茶素诱导的抗伤害作用[2]。BRL-15572(0.3-100.0 mg/kg；i.p.)是非活性的,BRL-15572(0.1-10 mg/kg；i.p.)对豚鼠的体温没有影响[3]。
• 参考文献:

  [1]. Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20.

  [2]. Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279.

  [3]. Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74.

BRL-15572 hydrochloride物理化学性质

• 分子式: C₂₅H₂₈Cl₂N₂O
• 分子量: 443.409
• 精确质量: 442.157867
• InChIKey: KQGJIKWDFWLCHO-UHFFFAOYSA-N
• SMILES: Cl.OC(CN1CCN(c2cccc(Cl)c2)CC1)C(c1ccccc1)c1ccccc1
• 储存条件: -20°C， 干燥

BRL-15572 hydrochloride靶点实验

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实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

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实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

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BRL-15572 hydrochloride英文别名

• 1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-, hydrochloride (1:1)
• 3-[4-(3-Chlorophenyl)-1-piperazinyl]-1,1-diphenyl-2-propanol hydrochloride (1:1)
• TCMDC-123456
• 3-[4-(3-Chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride (1:1)
• 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride