N-(4-羟基苯基)乙酰胺

• 常用名: N-(4-羟基苯基)乙酰胺
• 英文名: N-Acetyltyramine
• CAS号: 1202-66-0
• 分子量: 179.216
• 密度: 1.1±0.1 g/cm3
• 沸点: 424.1±28.0 °C at 760 mmHg
• 分子式: C₁₀H₁₃NO₂
• 熔点: 134°C
• 闪点: 210.3±24.0 °C
• 符号: GHS05
• 信号词: Danger

N-(4-羟基苯基)乙酰胺用途

N-Acetyltyramine 是溶藻弧菌 M3-10 产生的群体感应抑制剂 (QSI) 化合物。N-Acetyltyramine 能抑制 C. violaceum ATCC 12472 的群体感应 (QS)。N-Acetyltyramine 逆转阿霉素耐药白血病 P388 细胞的耐药性。

N-(4-羟基苯基)乙酰胺名称

• 中文名: N-乙酰基酪胺
• 英文名: N-[2-(4-hydroxyphenyl)ethyl]acetamide
• 中文别名: N-(4-羟基苯乙基)乙酰胺 | N-[2-(4-羟基苯基)乙基]乙酰胺

N-(4-羟基苯基)乙酰胺生物活性

• 描述: N-Acetyltyramine 是溶藻弧菌 M3-10 产生的群体感应抑制剂 (QSI) 化合物。N-Acetyltyramine 能抑制 C. violaceum ATCC 12472 的群体感应 (QS)。N-Acetyltyramine 逆转阿霉素耐药白血病 P388 细胞的耐药性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: N-乙酰酪胺增强了耐药P388小鼠白血病细胞中阿霉素的细胞毒性,IC50值为0.13μg/ml,而单用阿霉素的IC50值为0.48µg/ml[2]。
• 参考文献:

  [1]. Reina JC, et al. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar Drugs. 2019;17(9):494. Published 2019 Aug 24.

  [2]. Kunimoto S, et al. Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo). 1987;40(11):1651-1652.

N-(4-羟基苯基)乙酰胺物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 424.1±28.0 °C at 760 mmHg
• 熔点: 134°C
• 分子式: C₁₀H₁₃NO₂
• 分子量: 179.216
• 闪点: 210.3±24.0 °C
• 精确质量: 179.094635
• PSA: 49.33000
• LogP: 0.39
• InChIKey: ATDWJOOPFDQZNK-UHFFFAOYSA-N
• SMILES: CC(=O)NCCc1ccc(O)cc1
• 外观性状: 灰白色
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.546
• 储存条件: 2-8°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.1

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:3

  5.互变异构体数量:4

  6.拓扑分子极性表面积:49.3

  7.重原子数量:13

  8.表面电荷:0

  9.复杂度:162

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

N-(4-羟基苯基)乙酰胺MSDS

N-(4-羟基苯基)乙酰胺MSDS英文版

N-(4-羟基苯基)乙酰胺毒性和生态

N-(4-羟基苯基)乙酰胺安全信息

• 符号: GHS05
• 信号词: Danger
• 危害声明: H318
• 警示性声明: P280-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2924299090

N-(4-羟基苯基)乙酰胺海关

• 海关编码: 2924299090
• 中文概述: 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 包装
• Summary: 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-(4-羟基苯基)乙酰胺靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

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实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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N-(4-羟基苯基)乙酰胺英文别名

• GNF-PF-5230
• N-Acetyltyramine
• N-acetyltyramin
• N-[2-(4-Hydroxyphenyl)ethyl]acetamide