Withangulatin A

• 常用名: Withangulatin A
• 英文名: Withangulatin A
• CAS号: 120824-03-5
• 分子量: 526.61800
• 密度: 1.33g/cm3
• 沸点: 699.4ºC at 760mmHg
• 分子式: C₃₀H₃₈O₈
• 熔点: N/A
• 闪点: 227.7ºC

Withangulatin A用途

Withangulin A是一种选择性环氧合酶-2(COX-2)抑制剂。Withangulin A可从Physalis angulata L.中分离得到。Withangolin A具有抗肿瘤、胰蛋白酶活性和抗炎功能[1]。

Withangulatin A名称

• 英文名: Withangulatin A

Withangulatin A生物活性

• 描述: Withangulin A是一种选择性环氧合酶-2(COX-2)抑制剂。Withangulin A可从Physalis angulata L.中分离得到。Withangolin A具有抗肿瘤、胰蛋白酶活性和抗炎功能[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 参考文献:

  [1]. Lijuan Sun, et al. Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem. 2010 Feb 15;109(3):532-41.

Withangulatin A物理化学性质

• 密度: 1.33g/cm3
• 沸点: 699.4ºC at 760mmHg
• 分子式: C₃₀H₃₈O₈
• 分子量: 526.61800
• 闪点: 227.7ºC
• 精确质量: 526.25700
• PSA: 122.66000
• LogP: 2.95710
• InChIKey: PLPXOWZTDPJPHC-ISIACCJKSA-N
• SMILES: CC(=O)OC1C=C(C(C)C2CC(C)=C(C)C(=O)O2)C2(C)CCC3C(CC4OC45C(O)C=CC(=O)C35C)C12O
• 蒸汽压: 1.29E-22mmHg at 25°C
• 折射率: 1.606

Withangulatin A靶点实验

查看更多实验

实验名称：Covalent inhibition of TrxR (unknown origin) assessed as ratio of Kinact to ki incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4670488

实验名称：Antiproliferative activity against human HCT-116 cells assessed as reduction in cell ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4670475

实验名称：Inhibition of TrxR in human HT-29 cells incubated for 24 hrs in presence of insulin, ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4670507

实验名称：Antiproliferative activity against human HT-29 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4670474

实验名称：Inhibition of GR in human HT-29 cells incubated for 24 hrs in presence of GSSG and NA... 来源：ChEMBL 靶标：Glutathione reductase, mitochondrial External Id：CHEMBL4670509

实验名称：Antiproliferative activity against human MCF7 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4670477

实验名称：Inhibition of Trx in human HT-29 cells incubated for 24 hrs in presence of insulin, N... 来源：ChEMBL 靶标：Thioredoxin External Id：CHEMBL4670508

实验名称：Antiproliferative activity against human HepG2 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4670476

实验名称：Inhibition of GPx in human HT-29 cells incubated for 24 hrs in presence of GSH, NADPH... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4670510

实验名称：Covalent inhibition of TrxR (unknown origin) assessed as inactivation rate constant i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4670487

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Withangulatin A英文别名

• withagulatin A