埃格列净

• 常用名: 埃格列净
• 英文名: Ertugliflozin
• CAS号: 1210344-57-2
• 分子量: 436.883
• 密度: 1.5±0.1 g/cm3
• 沸点: 630.5±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅ClO₇
• 熔点: N/A
• 闪点: 335.1±31.5 °C

埃格列净用途

Ertugliflozin (PF-04971729) 是有效的、选择性的、具有口服活性的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 的抑制剂。其对h-SGLT2 的 IC50 值为0.877 nM[1][2]。是一种治疗2型糖尿病的临床药物[3]。

埃格列净名称

• 中文名: 埃格列净
• 英文名: (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

埃格列净生物活性

• 描述: Ertugliflozin (PF-04971729) 是有效的、选择性的、具有口服活性的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 的抑制剂。其对h-SGLT2 的 IC50 值为0.877 nM[1][2]。是一种治疗2型糖尿病的临床药物[3]。
• 相关类别:
  信号通路 >> 跨膜转运 >> SGLT
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 0.877 nM (h-SGLT2)[1].

• 体外研究: Ertugliflozin(PF-04971729)在体外对SGLT2抑制(相对于SGLT1)的选择性> 2000倍[3]。
• 体内研究: Ertugliflozin(PF-04971729)显示口服给予大鼠后浓度依赖性糖尿[3]。
• 参考文献:

  [1]. Mascitti V, et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60.

  [2]. Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56.

  [3]. Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19.

埃格列净物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 630.5±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅ClO₇
• 分子量: 436.883
• 闪点: 335.1±31.5 °C
• 精确质量: 436.128876
• PSA: 108.61000
• LogP: 6.49
• InChIKey: MCIACXAZCBVDEE-CUUWFGFTSA-N
• SMILES: CCOc1ccc(Cc2cc(C34OCC(CO)(O3)C(O)C(O)C4O)ccc2Cl)cc1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.652
• 储存条件: -20℃

埃格列净靶点实验

查看更多实验

实验名称：Human Sodium/glucose cotransporter 2 (Hexose transporter family) 来源：IUPHAR-DB 靶标：Sodium/glucose cotransporter 2 (Hexose transporter family) [Homo sapiens] External Id：916_Human

实验名称：Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [1... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 2 External Id：CHEMBL4015644

实验名称：Plasma clearance in Sprague-Dawley rat at 2 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1772501

实验名称：Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [1... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 1 External Id：CHEMBL4015645

实验名称：Selectivity ratio of IC50 for human SGLT1 expressed in CHO cells to IC50 for human SG... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4015646

实验名称：Human Sodium/glucose cotransporter 1 (Hexose transporter family) 来源：IUPHAR-DB 靶标：Sodium/glucose cotransporter 1 (Hexose transporter family) [Homo sapiens] External Id：915_Human

实验名称：Oral bioavailability in rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL5247062

实验名称：Metabolic stability in human liver microsomes assessed as retention time at 10 mg by ... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3540035

实验名称：Drug recovery in beagle dog at 10 mg/kg, po after 1 to 144 hrs 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL3540326

实验名称：Oral bioavailability in dog 来源：ChEMBL 靶标：N/A External Id：CHEMBL5247059

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埃格列净英文别名

• (1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
• Ertugliflozin
• PF-04971729
• Ertugliflozin (USAN/INN)
• PF-04971729-00
• MK-8835
• cc-212
• (1S,2S,3S,4R,5S)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1-hydroxymethyl-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol