MK-7622

• 常用名: MK-7622
• 英文名: MK-7622
• CAS号: 1227923-29-6
• 分子量: 399.485
• 密度: 1.3±0.1 g/cm3
• 沸点: 643.0±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅N₃O₂
• 熔点: N/A
• 闪点: 342.7±34.3 °C

MK-7622用途

MK-7622 是一种毒蕈碱M1受体正变构调节剂。

MK-7622名称

• 中文名: MK-7622
• 英文名: 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]b enzo[h]quinazolin-4(3H)-one

MK-7622生物活性

• 描述: MK-7622 是一种毒蕈碱M1受体正变构调节剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kuduk Scott D, et al. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators. From PCT Int. Appl. (2012), WO 2012047702 A1 20120412.

  [2]. Kuduk Scott D, et al. Benzoquinazolinone derivatives as M1 receptor positive allosteric modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases. From PCT Int. Appl. (2010), WO 2010059773 A1 20100527.

MK-7622物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 643.0±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅N₃O₂
• 分子量: 399.485
• 闪点: 342.7±34.3 °C
• 精确质量: 399.194672
• PSA: 68.01000
• LogP: 3.37
• InChIKey: JUVQLZBJFOGEEO-GOTSBHOMSA-N
• SMILES: Cc1ccc(Cc2cc3c(=O)n(C4CCCCC4O)cnc3c3ccccc23)cn1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.687
• 储存条件: -20°C，密闭，干燥

MK-7622靶点实验

查看更多实验

实验名称：Ratio of unbound Cmax in rat brain assessed as convulsions at 45 mg/kg, po administer... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4018502

实验名称：Inhibition of human ERG 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4199666

实验名称：Ratio of unbound AUC in rat brain to plasma at 45 mg/kg, po administered as single do... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4018499

实验名称：Agonist activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL4199651

实验名称：Agonist activity at human muscarinic acetylcholine receptor M4 expressed in CHO cells 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4 External Id：CHEMBL4199650

实验名称：Antialzheimer activity in mouse assessed as reversal of scopolamine-induced emotional... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4199662

实验名称：Ratio of unbound brain concentration required for reversal of scopolamine-induced emo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4199665

实验名称：Agonist activity at human muscarinic acetylcholine receptor M1 expressed in CHO cells... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL4018428

实验名称：Induction of CYP3A4 mRNA expression in human hepatocytes at 0.1 to 10 uM 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL4199659

实验名称：Induction of CYP3A4 activity in human hepatocytes at 0.1 to 10 uM 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4199660

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MK-7622英文别名

• 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4(3H)-one
• (S)-3-(1-AMINOETHYL)BENZENAMINE
• 3-[(1S)-1-azanylethyl]aniline
• (S)-1-(3-Aminophenyl)-1-aminoethane
• 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one
• MK-7622