多西他赛

• 常用名: 多西他赛
• 英文名: Docetaxal
• CAS号: 125354-16-7
• 分子量: 849.916
• 密度: 1.4±0.1 g/cm3
• 沸点: 901.4±65.0 °C at 760 mmHg
• 分子式: C₄₅H₅₅NO₁₅
• 熔点: N/A
• 闪点: 499.0±34.3 °C

多西他赛用途

Docetaxal (10-Acetyl docetaxel; PNU-101383) 是一种 Docetaxel (HY-B0011) 类似物。Docetaxal 是一微管拆卸 microtubule disassembly 抑制剂,具有抗有丝分裂活性。Docetaxal 对小鼠白血病细胞具有细胞毒性。

多西他赛名称

• 中文名: 10-乙酰多西他赛
• 英文名: Docetaxel
• 中文别名: 三水多西他赛

多西他赛生物活性

• 描述: Docetaxal (10-Acetyl docetaxel; PNU-101383) 是一种 Docetaxel (HY-B0011) 类似物。Docetaxal 是一微管拆卸 microtubule disassembly 抑制剂,具有抗有丝分裂活性。Docetaxal 对小鼠白血病细胞具有细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 体外研究: 多西他赛对小鼠P388白血病细胞具有细胞毒性,IC50为8.24μM[1]。
• 参考文献:

  [1]. Gueritte-Voegelein, et al. Relationships between the structure of taxol analogs and their antimitotic activity. Journal of Medicinal Chemistry, 1991. 34(3), 992–998.

多西他赛物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 901.4±65.0 °C at 760 mmHg
• 分子式: C₄₅H₅₅NO₁₅
• 分子量: 849.916
• 闪点: 499.0±34.3 °C
• 精确质量: 849.357178
• PSA: 230.52000
• LogP: 7.19
• InChIKey: LEMYAXKYCOBYOJ-OAGWZNDDSA-N
• SMILES: CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C1C2(C)C
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.606
• 储存条件: 2-8°C，密封，干燥

多西他赛安全信息

• 海关编码: 2932999099

多西他赛海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

多西他赛靶点实验

查看更多实验

实验名称：Cytotoxicity was measured as ratio of its IC50 value to that of compound 13a 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL851779

实验名称：Antiproliferative activity against human A549 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3399186

实验名称：Antiproliferative activity against human HepG2 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3399189

实验名称：Antiproliferative activity against human A2780 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL3399190

实验名称：Antiproliferative activity against human SW480 cells assessed as growth inhibition af... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL3399187

实验名称：The concentration required to 50% inhibition of the P388 leukemic cell proliferation 来源：ChEMBL 靶标：P388 External Id：CHEMBL756789

实验名称：Antiproliferative activity against human MCF7 cells assessed as growth inhibition aft... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3399188

实验名称：Antiproliferative activity against human HCT8/VCT cells assessed as growth inhibition... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399193

实验名称：Antiproliferative activity against human A549/CDDP cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399194

实验名称：Antiproliferative activity against human A2780/TAX cells assessed as growth inhibitio... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3399191

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多西他赛英文别名

• (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• N-DEBENZOYL-N-(TERT-BUTOXYCARBONYL)TAXOL
• 10-Acetyldocetaxel
• 10-Acetyltaxotere
• Docetaxal
• DOCETAXOL
• (2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• DOCETAXEL TRIHYDRATE
• DOCETAXEL, TRIHYDRATE
• DOCETAXEL,TRIHYDRATE