QWF

• 常用名: QWF
• 英文名: QWF
• CAS号: 126088-82-2
• 分子量: 697.78
• 密度: 1.26g/cm3
• 沸点: N/A
• 分子式: C₃₈H₄₃N₅O₈
• 熔点: N/A
• 闪点: N/A

QWF用途

QWF Peptide (Compound 4a) 是一种 substance P 拮抗剂,其 IC50 为 0.09 μM。QWF Peptide 拮抗 SP 诱导的豚鼠离体气管条收缩,其 IC50 为 4.7 μM。

QWF名称

• 英文名: benzyl (2S)-2-[[(2R)-2-[[(2S)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoyl]amino]-3-(1-formylindol-3-yl)propanoyl]amino]-3-phenylpropanoate

QWF生物活性

• 描述: QWF Peptide (Compound 4a) 是一种 substance P 拮抗剂,其 IC50 为 0.09 μM。QWF Peptide 拮抗 SP 诱导的豚鼠离体气管条收缩,其 IC50 为 4.7 μM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 神经激肽受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
• 靶点实验:

  IC50: 0.09 μM (substance P)[1]

• 参考文献:

  [1]. Hagiwara D, et al. Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J Med Chem. 1992 May 29;35(11):2015-25.

QWF物理化学性质

• 密度: 1.26g/cm3
• 分子式: C₃₈H₄₃N₅O₈
• 分子量: 697.78
• 精确质量: 697.31100
• PSA: 199.38000
• LogP: 6.97340
• InChIKey: ZFZOHFAASQHWER-YPKYBTACSA-N
• SMILES: CC(C)(C)OC(=O)NC(CCC(N)=O)C(=O)NC(Cc1cn(C=O)c2ccccc12)C(=O)NC(Cc1ccccc1)C(=O)OCc1ccccc1
• 折射率: 1.609

QWF靶点实验

查看更多实验

实验名称：Suppression of bilirubin-induced pruritus in mouse assessed as reduction in scratchin... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420053

实验名称：Suppression of chloroquine-induced pruritus in mouse assessed as reduction in scratch... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420054

实验名称：Suppression of ANIT-induced cholestatic pruritus in mouse assessed as reduction in sc... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420055

实验名称：Suppression of ANIT-induced cholestatic liver injury in mouse assessed as effect on t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420056

实验名称：Suppression of ANIT-induced cholestatic liver injury in mouse assessed as effect on A... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420057

实验名称：Suppression of ANIT-induced cholestatic liver injury in mouse assessed as effect on A... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420058

实验名称：Suppression of ANIT-induced cholestatic liver injury in mouse assessed as effect on A... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4420059

实验名称：Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated... 来源：ChEMBL 靶标：Substance-P receptor External Id：CHEMBL812234

实验名称：Inhibition of [3H]SP binding to guinea pig trachea strips 来源：ChEMBL 靶标：N/A External Id：CHEMBL812231

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QWF英文别名

• (R)-2-Amino-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid
• BOC-D-tryptophan
• Boc-Gln-D-Trp(CHO)-Phe-OBzl