东北贯众素

• 常用名: 东北贯众素
• 英文名: dryocrassin ABBA
• CAS号: 12777-70-7
• 分子量: 820.832
• 密度: 1.5±0.1 g/cm3
• 沸点: 1089.0±65.0 °C at 760 mmHg
• 分子式: C₄₃H₄₈O₁₆
• 熔点: N/A
• 闪点: 626.1±30.8 °C

东北贯众素用途

Dryocrassin ABBA (Dryocrassin) 是从苦参中提取的黄酮类天然产物,具有抗病毒、抗菌活性。Dryocrassin ABBA 对 H5N1 禽流感病毒具有抗病毒活性。Dryocrassin ABBA 能抑制金黄色葡萄球菌 vWbp 的凝固酶活性。Dryocrassin ABBA 能抑制树突状细胞的免疫刺激功能,延长同种异体皮肤移植成活率。

东北贯众素名称

• 中文名: 东北贯众素
• 英文名: 2-acetyl-4-[[3-[[3-[(5-acetyl-2,6-dihydroxy-3,3-dimethyl-4-oxocyclohexa-1,5-dien-1-yl)methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-5-butanoyl-2,4,6-trihydroxyphenyl]methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one
• 中文别名: 东北贯众素 | 白绵马酸ABBA | 绵马贯众素ABBA

东北贯众素生物活性

• 描述: Dryocrassin ABBA (Dryocrassin) 是从苦参中提取的黄酮类天然产物,具有抗病毒、抗菌活性。Dryocrassin ABBA 对 H5N1 禽流感病毒具有抗病毒活性。Dryocrassin ABBA 能抑制金黄色葡萄球菌 vWbp 的凝固酶活性。Dryocrassin ABBA 能抑制树突状细胞的免疫刺激功能,延长同种异体皮肤移植成活率。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  H5N1 avian influenza virus[1]

• 参考文献:

  [1]. Ou C, et al. Dryocrassin ABBA, a novel active substance for use against amantadine-resistant H5N1 avian influenza virus. Front Microbiol. 2015 Jun 16;6:592.

  [2]. Zhang B, et al. Molecular Mechanism of the Flavonoid Natural Product Dryocrassin ABBA against Staphylococcus aureus Sortase A. Molecules. 2016 Oct 26;21(11).

  [3]. Li B, et al. An Inhibitory Effect of Dryocrassin ABBA on Staphylococcus aureus vWbp That Protects Mice From Pneumonia. Front Microbiol. 2019 Jan 23;10:7.

  [4]. Fu RH, et al. Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival. Cell Transplant. 2014;23(4-5):641-56.

东北贯众素物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1089.0±65.0 °C at 760 mmHg
• 分子式: C₄₃H₄₈O₁₆
• 分子量: 820.832
• 闪点: 626.1±30.8 °C
• 精确质量: 820.294250
• PSA: 304.72000
• LogP: 8.08
• InChIKey: PRVKSKWNDSLRBY-UHFFFAOYSA-N
• SMILES: CCCC(=O)c1c(O)c(CC2=C(O)C(C)(C)C(=O)C(C(C)=O)=C2O)c(O)c(Cc2c(O)c(CC3=C(O)C(C)(C)C(=O)C(C(C)=O)=C3O)c(O)c(C(=O)CCC)c2O)c1O
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.673

东北贯众素英文别名

• 2,2'-{Methylenebis[(5-butyryl-2,4,6-trihydroxy-3,1-phenylene)methylene]}bis(6-acetyl-3,5-dihydroxy-4,4-dimethyl-2,5-cyclohexadien-1-one)
• 2,5-Cyclohexadien-1-one,2,2'-(methylenebis((2,4,6-trihydroxy-5-(1-oxobutyl)-3,1-phenylene)methylene)bis(6-acetyl-3,5-dihydroxy
• Y0072
• 4,4'-{Methylenebis[(5-butyryl-2,4,6-trihydroxy-3,1-phenylene)methylene]}bis(2-acetyl-3,5-dihydroxy-6,6-dimethyl-2,4-cyclohexadien-1-one)
• tetraalbaspidin-ABBA
• Dryocrassin ABBA
• Dryocrassin