盐酸哌罗匹隆

• 常用名: 盐酸哌罗匹隆
• 英文名: Perospirone hydrochloride
• CAS号: 129273-38-7
• 分子量: 463.036
• 密度: N/A
• 沸点: 667.4ºC at 760 mmHg
• 分子式: C₂₃H₃₁ClN₄O₂S
• 熔点: 95-970ºC
• 闪点: 357.4ºC

盐酸哌罗匹隆用途

Perospirone hydrochloride (SM-9018) 是具有口服活性的 5-HT2A 受体 (Ki 为 0.6 nM) 和多巴胺 D2 受体 (Ki 为 1.4 nM) 的拮抗剂,也是 5-HT1A 受体 (Ki 为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂,可用于精神分裂症的研究。

盐酸哌罗匹隆名称

• 中文名: 盐酸哌罗匹隆
• 英文名: Perospirone Hydrochloride Trihydrate
• 中文别名: N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐

盐酸哌罗匹隆生物活性

• 描述: Perospirone hydrochloride (SM-9018) 是具有口服活性的 5-HT2A 受体 (Ki 为 0.6 nM) 和多巴胺 D2 受体 (Ki 为 1.4 nM) 的拮抗剂,也是 5-HT1A 受体 (Ki 为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂,可用于精神分裂症的研究。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 靶点实验:

  5-HT2A Receptor:0.6 nM (Ki)

  D2 Receptor:1.4 nM (Ki)

  5-HT1A Receptor:2.9 nM (Ki)

  5-HT1 Receptor:18 nM (Ki)

  D1 Receptor:41 nM (Ki)

• 参考文献:

  [1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81.

  [2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54.

盐酸哌罗匹隆物理化学性质

• 沸点: 667.4ºC at 760 mmHg
• 熔点: 95-970ºC
• 分子式: C₂₃H₃₁ClN₄O₂S
• 分子量: 463.036
• 闪点: 357.4ºC
• 精确质量: 462.185638
• PSA: 84.99000
• LogP: 4.11650
• InChIKey: HIZFAPMOZFYELI-GNXQHMNLSA-N
• SMILES: Cl.O=C1C2CCCCC2C(=O)N1CCCCN1CCN(c2nsc3ccccc23)CC1
• 外观性状: 白色固体
• 储存条件: -20°C Freezer

盐酸哌罗匹隆毒性和生态

盐酸哌罗匹隆靶点实验

查看更多实验

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盐酸哌罗匹隆英文别名

• MFCD08457543
• Perospirone hydrochloride
• (3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)
• 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-, hydrochloride (1:1)