Sephin-1

• 常用名: Sephin-1
• 英文名: Sephin-1
• CAS号: 13098-73-2
• 分子量: 196.63700
• 密度: 1.35g/cm3
• 沸点: 374.2ºC at 760 mmHg
• 分子式: C₈H₉ClN₄
• 熔点: N/A
• 闪点: 180.1ºC

Sephin-1用途

(E/Z)-冰rguastat((E/Z)-Sephin1)是磷酸酶调节亚单位PPP1R15A(R15A)的选择性抑制剂。(E/Z)-冰rguastat可用于蛋白质错误折叠疾病的研究[1]。

Sephin-1名称

• 英文名: 2-[(E)-(2-chlorophenyl)methylideneamino]guanidine

Sephin-1生物活性

• 描述: (E/Z)-冰rguastat((E/Z)-Sephin1)是磷酸酶调节亚单位PPP1R15A(R15A)的选择性抑制剂。(E/Z)-冰rguastat可用于蛋白质错误折叠疾病的研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  PPP1R15A[1]

• 参考文献:

  [1]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42.

Sephin-1物理化学性质

• 密度: 1.35g/cm3
• 沸点: 374.2ºC at 760 mmHg
• 分子式: C₈H₉ClN₄
• 分子量: 196.63700
• 闪点: 180.1ºC
• 精确质量: 196.05200
• PSA: 74.26000
• LogP: 2.34790
• 蒸汽压: 8.5E-06mmHg at 25°C
• 折射率: 1.626

Sephin-1靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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Sephin-1英文别名

• Sephin-1